Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure
Although the mechanism of the occurrence and development of heart failure has been continuously explored in the past ten years, the mortality and readmission rate of heart failure is still very high. Modern studies have shown that gut microbiota is associated with a variety of cardiovascular disease...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2019/5164298 |
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| _version_ | 1832559395915956224 |
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| author | Qiujin Jia Hao Li Huan Zhou Xiaonan Zhang Ao Zhang Yingyu Xie Yanyang Li Shichao Lv Junping Zhang |
| author_facet | Qiujin Jia Hao Li Huan Zhou Xiaonan Zhang Ao Zhang Yingyu Xie Yanyang Li Shichao Lv Junping Zhang |
| author_sort | Qiujin Jia |
| collection | DOAJ |
| description | Although the mechanism of the occurrence and development of heart failure has been continuously explored in the past ten years, the mortality and readmission rate of heart failure is still very high. Modern studies have shown that gut microbiota is associated with a variety of cardiovascular diseases, among which the study of gut microbiota and heart failure attracts particular attention. Therefore, understanding the role of gut microbiota in the occurrence and development of heart failure will help us further understand the pathogenesis of heart failure and provide new ideas for its treatment. This paper introduced intestinal flora and its metabolites, summarized the changes of intestinal flora in patients with heart failure, clarified that intestinal barrier damage and bacterial translocation induced inflammation and immune response aggravated heart failure, and altered intestinal microflora affected various metabolic pathways including trimethylamine/TMAO, SCFA, and Bile acid pathway leads to heart failure. At the same time, regulating intestinal microflora through diet, probiotics, antibiotics, fecal transplantation and microbial enzyme inhibitors has grown up to be a potential treatment for many metabolic disorders. |
| format | Article |
| id | doaj-art-100aa8be771848dcacaeedfdcf305144 |
| institution | Kabale University |
| issn | 1755-5914 1755-5922 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-100aa8be771848dcacaeedfdcf3051442025-02-03T01:30:11ZengWileyCardiovascular Therapeutics1755-59141755-59222019-01-01201910.1155/2019/51642985164298Role and Effective Therapeutic Target of Gut Microbiota in Heart FailureQiujin Jia0Hao Li1Huan Zhou2Xiaonan Zhang3Ao Zhang4Yingyu Xie5Yanyang Li6Shichao Lv7Junping Zhang8First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaAffiliated Hospital of Nankai University, 4 Wei Shan Road, He Xi District, Tianjin 300222, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaEpidemiology, College of Global Public Health, New York University, 726 Broadway, New York, NY 10003, USATianjin University of Traditional Chinese Medicine, 10 Po Yang Lake Road, Tuan Bo New Town West, Jing Hai District, Tianjin 301617, ChinaTianjin Medical University Cancer Institute and Hospital, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 314 An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaAlthough the mechanism of the occurrence and development of heart failure has been continuously explored in the past ten years, the mortality and readmission rate of heart failure is still very high. Modern studies have shown that gut microbiota is associated with a variety of cardiovascular diseases, among which the study of gut microbiota and heart failure attracts particular attention. Therefore, understanding the role of gut microbiota in the occurrence and development of heart failure will help us further understand the pathogenesis of heart failure and provide new ideas for its treatment. This paper introduced intestinal flora and its metabolites, summarized the changes of intestinal flora in patients with heart failure, clarified that intestinal barrier damage and bacterial translocation induced inflammation and immune response aggravated heart failure, and altered intestinal microflora affected various metabolic pathways including trimethylamine/TMAO, SCFA, and Bile acid pathway leads to heart failure. At the same time, regulating intestinal microflora through diet, probiotics, antibiotics, fecal transplantation and microbial enzyme inhibitors has grown up to be a potential treatment for many metabolic disorders.http://dx.doi.org/10.1155/2019/5164298 |
| spellingShingle | Qiujin Jia Hao Li Huan Zhou Xiaonan Zhang Ao Zhang Yingyu Xie Yanyang Li Shichao Lv Junping Zhang Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure Cardiovascular Therapeutics |
| title | Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure |
| title_full | Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure |
| title_fullStr | Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure |
| title_full_unstemmed | Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure |
| title_short | Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure |
| title_sort | role and effective therapeutic target of gut microbiota in heart failure |
| url | http://dx.doi.org/10.1155/2019/5164298 |
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