Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes
Abstract Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07493-2 |
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| author | Yuting Wei Huirong Mao Qiuhong Liu Wenjie Fang Tianxiang Zhang Yongtao Xu Weiwei Zhang Biao Chen Yunlin Zheng Xiaolong Hu |
| author_facet | Yuting Wei Huirong Mao Qiuhong Liu Wenjie Fang Tianxiang Zhang Yongtao Xu Weiwei Zhang Biao Chen Yunlin Zheng Xiaolong Hu |
| author_sort | Yuting Wei |
| collection | DOAJ |
| description | Abstract Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism and potential microbial regulatory mechanisms in hibernating snakes, the serum, liver, gut content samples were measured by multi-omic methods. Here we show the active snakes have more vigorous lipid metabolism, whereas snakes in hibernation groups have higher sphingolipid metabolism. Furthermore, the results indicate that the potential energy supply pathway was gluconeogenesis. Microbial analysis reveals that Proteobacteria and Firmicutes showed dynamic changes with the transformation among active, pre-hibernation and hibernation periods. The correlation analysis reveals the potential role of Romboutsia, Providencia and Vagococcus in regulating above metabolism by producing certain metabolites. The results advance the understanding of the complex energy-saving strategy in hibernating poikilotherms. |
| format | Article |
| id | doaj-art-1003683d052d4ed889e52590cfe568bf |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-1003683d052d4ed889e52590cfe568bf2025-01-19T12:35:37ZengNature PortfolioCommunications Biology2399-36422025-01-018111310.1038/s42003-025-07493-2Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakesYuting Wei0Huirong Mao1Qiuhong Liu2Wenjie Fang3Tianxiang Zhang4Yongtao Xu5Weiwei Zhang6Biao Chen7Yunlin Zheng8Xiaolong Hu9College of Animal Science and Technology, Jiangxi Agricultural UniversityCollege of Animal Science and Technology, Jiangxi Agricultural UniversityCollege of Animal Science and Technology, Jiangxi Agricultural UniversityCollege of Animal Science and Technology, Jiangxi Agricultural UniversityInstitute of Wildlife Conservation, Jiangxi Academy of ForestryJiangxi Provincial Key Laboratory of Conservation Biology, Jiangxi Agricultural UniversityJiangxi Provincial Key Laboratory of Conservation Biology, Jiangxi Agricultural UniversityCollege of Animal Science and Technology, Jiangxi Agricultural UniversityCollege of Animal Science and Technology, Jiangxi Agricultural UniversityCollege of Animal Science and Technology, Jiangxi Agricultural UniversityAbstract Hibernation is a necessary means for animals to maintain survival while coping with low temperatures and food shortages. While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. In order to provide insights into the energy metabolism and potential microbial regulatory mechanisms in hibernating snakes, the serum, liver, gut content samples were measured by multi-omic methods. Here we show the active snakes have more vigorous lipid metabolism, whereas snakes in hibernation groups have higher sphingolipid metabolism. Furthermore, the results indicate that the potential energy supply pathway was gluconeogenesis. Microbial analysis reveals that Proteobacteria and Firmicutes showed dynamic changes with the transformation among active, pre-hibernation and hibernation periods. The correlation analysis reveals the potential role of Romboutsia, Providencia and Vagococcus in regulating above metabolism by producing certain metabolites. The results advance the understanding of the complex energy-saving strategy in hibernating poikilotherms.https://doi.org/10.1038/s42003-025-07493-2 |
| spellingShingle | Yuting Wei Huirong Mao Qiuhong Liu Wenjie Fang Tianxiang Zhang Yongtao Xu Weiwei Zhang Biao Chen Yunlin Zheng Xiaolong Hu Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes Communications Biology |
| title | Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes |
| title_full | Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes |
| title_fullStr | Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes |
| title_full_unstemmed | Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes |
| title_short | Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes |
| title_sort | lipid metabolism and microbial regulation analyses provide insights into the energy saving strategies of hibernating snakes |
| url | https://doi.org/10.1038/s42003-025-07493-2 |
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