Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients
Background. Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis-related processes. However, the prognostic significance of m6A-related lncRNAs and their associations with stemness in low-grade glioma (LGG) remain...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2024/2062283 |
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| author | Dahua Xu Peihu Li Chunrui Zhang Yutong Shen Jiale Cai Qingchen Wei Meng Cao Zhizhou Xu Deng Wu Hong Wang Xiaoman Bi Bo Wang Kongning Li |
| author_facet | Dahua Xu Peihu Li Chunrui Zhang Yutong Shen Jiale Cai Qingchen Wei Meng Cao Zhizhou Xu Deng Wu Hong Wang Xiaoman Bi Bo Wang Kongning Li |
| author_sort | Dahua Xu |
| collection | DOAJ |
| description | Background. Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis-related processes. However, the prognostic significance of m6A-related lncRNAs and their associations with stemness in low-grade glioma (LGG) remain to be clarified. Methods. A multicenter transcriptome analysis of lncRNA expression in 1,247 LGG samples was performed in this study. The stemness landscape of LGG tumors was presented and associations with clinical features were revealed. The m6A-related lncRNAs were identified between stemness groups and were further prioritized via least absolute shrinkage and selection operator Cox regression analysis. A risk score model based on m6A-related lncRNAs was constructed and validated in external LGG datasets. Results. Based on the expression of LINC02984, PFKP-DT, and CRNDE, a risk model and nomogram were constructed; they successfully predicted the survival of patients and were extended to external datasets. Significant correlations were observed between the risk score and tumor stemness. Moreover, patients in different risk groups exhibited distinct tumor immune microenvironments and immune signatures. We finally provided several potential compounds suitable for specific risk groups, which may aid in LGG treatment. Conclusions. This novel signature presents noteworthy value in the prediction of prognosis and stemness status for LGG patients and will foster future research on the development of clinical regimens. |
| format | Article |
| id | doaj-art-0fff1f3f3bae4099b201256ee26a8bc2 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0fff1f3f3bae4099b201256ee26a8bc22025-02-03T01:29:50ZengWileyStem Cells International1687-96782024-01-01202410.1155/2024/2062283Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma PatientsDahua Xu0Peihu Li1Chunrui Zhang2Yutong Shen3Jiale Cai4Qingchen Wei5Meng Cao6Zhizhou Xu7Deng Wu8Hong Wang9Xiaoman Bi10Bo Wang11Kongning Li12Key Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationInstitute of Genetics and Developmental BiologyKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationSchool of Life SciencesKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationKey Laboratory of Tropical Translational Medicine of Ministry of EducationBackground. Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis-related processes. However, the prognostic significance of m6A-related lncRNAs and their associations with stemness in low-grade glioma (LGG) remain to be clarified. Methods. A multicenter transcriptome analysis of lncRNA expression in 1,247 LGG samples was performed in this study. The stemness landscape of LGG tumors was presented and associations with clinical features were revealed. The m6A-related lncRNAs were identified between stemness groups and were further prioritized via least absolute shrinkage and selection operator Cox regression analysis. A risk score model based on m6A-related lncRNAs was constructed and validated in external LGG datasets. Results. Based on the expression of LINC02984, PFKP-DT, and CRNDE, a risk model and nomogram were constructed; they successfully predicted the survival of patients and were extended to external datasets. Significant correlations were observed between the risk score and tumor stemness. Moreover, patients in different risk groups exhibited distinct tumor immune microenvironments and immune signatures. We finally provided several potential compounds suitable for specific risk groups, which may aid in LGG treatment. Conclusions. This novel signature presents noteworthy value in the prediction of prognosis and stemness status for LGG patients and will foster future research on the development of clinical regimens.http://dx.doi.org/10.1155/2024/2062283 |
| spellingShingle | Dahua Xu Peihu Li Chunrui Zhang Yutong Shen Jiale Cai Qingchen Wei Meng Cao Zhizhou Xu Deng Wu Hong Wang Xiaoman Bi Bo Wang Kongning Li Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients Stem Cells International |
| title | Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients |
| title_full | Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients |
| title_fullStr | Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients |
| title_full_unstemmed | Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients |
| title_short | Development of an m6A-Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low-Grade Glioma Patients |
| title_sort | development of an m6a related lncrnas signature predicts tumor stemness and prognosis for low grade glioma patients |
| url | http://dx.doi.org/10.1155/2024/2062283 |
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