Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker
Postsynaptic protein neurogranin (Ng), which plays a role in synaptic plasticity, learning, and memory, has been identified as the candidate biomarker of Alzheimer's disease (AD). Cortical Amyloid β pathology seems to accelerate the onset of clinical symptoms; therefore, it is potentially valua...
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AIMS Press
2024-09-01
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| Series: | AIMS Molecular Science |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/molsci.2024020 |
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| author | Rajkumar Bavaharini Chaitanya Sree Somala Konda Mani Saravanan Thirunavukarasou Anand |
| author_facet | Rajkumar Bavaharini Chaitanya Sree Somala Konda Mani Saravanan Thirunavukarasou Anand |
| author_sort | Rajkumar Bavaharini |
| collection | DOAJ |
| description | Postsynaptic protein neurogranin (Ng), which plays a role in synaptic plasticity, learning, and memory, has been identified as the candidate biomarker of Alzheimer's disease (AD). Cortical Amyloid β pathology seems to accelerate the onset of clinical symptoms; therefore, it is potentially valuable for early diagnosis of AD and therapeutic intervention. Synaptic pathology was shown to be an early feature of AD. Thus, proteins involved in synaptic function, such as Ng, are of great interest in studying the disease. Some prior human studies have found that Ng, a protein involved in the regulation of synaptic function, is present at greater levels in the cerebrospinal fluid of people with AD compared with those without the disease. High levels of neurogranin are associated with increased levels of synaptic vulnerability and decreased cognitive function in AD patients. This review, therefore, looked at the functionality of Ng in the brain, its association with other synaptic proteins, and its applicability as a diagnostic marker in AD. This study, therefore, sought to expand the knowledge on Ng changes in AD as it relates to synaptic dysfunction and enhanced the search for a better diagnostic and therapeutic approach. |
| format | Article |
| id | doaj-art-0ffa0be55372426ca996630c6a5aa034 |
| institution | Kabale University |
| issn | 2372-0301 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Molecular Science |
| spelling | doaj-art-0ffa0be55372426ca996630c6a5aa0342025-01-24T01:33:38ZengAIMS PressAIMS Molecular Science2372-03012024-09-0111433035010.3934/molsci.2024020Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarkerRajkumar Bavaharini0Chaitanya Sree Somala1Konda Mani Saravanan2Thirunavukarasou Anand3Department of Plant Biotechnology, Centre for Plant Molecular Biology and Biotechnology, Tamil Nadu Agricultural University, Coimbatore – 641003, Tamil Nadu, IndiaB Aatral Biosciences Private Limited, Bangalore 560091, Karnataka, IndiaB Aatral Biosciences Private Limited, Bangalore 560091, Karnataka, IndiaSRIIC Lab, Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research, Chennai 600116, Tamil Nadu, IndiaPostsynaptic protein neurogranin (Ng), which plays a role in synaptic plasticity, learning, and memory, has been identified as the candidate biomarker of Alzheimer's disease (AD). Cortical Amyloid β pathology seems to accelerate the onset of clinical symptoms; therefore, it is potentially valuable for early diagnosis of AD and therapeutic intervention. Synaptic pathology was shown to be an early feature of AD. Thus, proteins involved in synaptic function, such as Ng, are of great interest in studying the disease. Some prior human studies have found that Ng, a protein involved in the regulation of synaptic function, is present at greater levels in the cerebrospinal fluid of people with AD compared with those without the disease. High levels of neurogranin are associated with increased levels of synaptic vulnerability and decreased cognitive function in AD patients. This review, therefore, looked at the functionality of Ng in the brain, its association with other synaptic proteins, and its applicability as a diagnostic marker in AD. This study, therefore, sought to expand the knowledge on Ng changes in AD as it relates to synaptic dysfunction and enhanced the search for a better diagnostic and therapeutic approach.https://www.aimspress.com/article/doi/10.3934/molsci.2024020neurograninalzheimer's diseasebiomarkerssynaptic dysfunctioncognitive decline |
| spellingShingle | Rajkumar Bavaharini Chaitanya Sree Somala Konda Mani Saravanan Thirunavukarasou Anand Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker AIMS Molecular Science neurogranin alzheimer's disease biomarkers synaptic dysfunction cognitive decline |
| title | Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker |
| title_full | Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker |
| title_fullStr | Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker |
| title_full_unstemmed | Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker |
| title_short | Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker |
| title_sort | neurogranin in alzheimer s disease roles in synaptic function pathology and potential as a diagnostic biomarker |
| topic | neurogranin alzheimer's disease biomarkers synaptic dysfunction cognitive decline |
| url | https://www.aimspress.com/article/doi/10.3934/molsci.2024020 |
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