New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease
Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. Graft-versus-host disease (GVHD) remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a br...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/701013 |
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| _version_ | 1832551994737295360 |
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| author | Florent Malard Mohamad Mohty |
| author_facet | Florent Malard Mohamad Mohty |
| author_sort | Florent Malard |
| collection | DOAJ |
| description | Allogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. Graft-versus-host disease (GVHD) remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Early diagnostic of GVHD is essential to initiate treatment as soon as possible. Unfortunately, the diagnosis of GVHD may be difficult to establish, because of the nonspecific nature of the associated symptoms and of the numerous differential diagnosis. This is particularly true regarding gastrointestinal (GI) acute GVHD. In the recent years many progress has been made in medical imaging test and endoscopic techniques. The interest of these different techniques in the diagnosis of GI acute GVHD has been evaluated in several studies. With this background we review the contributions, limitations, and future prospect of these techniques in the diagnosis of GI acute GVHD. |
| format | Article |
| id | doaj-art-0ff0b7937d314209b2080f947ff340a0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0ff0b7937d314209b2080f947ff340a02025-02-03T05:59:46ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/701013701013New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host DiseaseFlorent Malard0Mohamad Mohty1Service d’Hématologie Clinique, Centre Hospitalier et Universitaire (CHU), CHU Hôtel-Dieu, Place Alexis Ricordeau, 44093 Nantes, FranceUniversité Pierre et Marie Curie, INSERM, UMRs 938, 184 rue du Faubourg Saint-Antoine, 75012 Paris, FranceAllogeneic stem cell transplantation (allo-SCT) is a curative therapy for different life-threatening malignant and nonmalignant hematologic disorders. Graft-versus-host disease (GVHD) remains a major source of morbidity and mortality following allo-SCT, which limits the use of this treatment in a broader spectrum of patients. Early diagnostic of GVHD is essential to initiate treatment as soon as possible. Unfortunately, the diagnosis of GVHD may be difficult to establish, because of the nonspecific nature of the associated symptoms and of the numerous differential diagnosis. This is particularly true regarding gastrointestinal (GI) acute GVHD. In the recent years many progress has been made in medical imaging test and endoscopic techniques. The interest of these different techniques in the diagnosis of GI acute GVHD has been evaluated in several studies. With this background we review the contributions, limitations, and future prospect of these techniques in the diagnosis of GI acute GVHD.http://dx.doi.org/10.1155/2014/701013 |
| spellingShingle | Florent Malard Mohamad Mohty New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease Mediators of Inflammation |
| title | New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease |
| title_full | New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease |
| title_fullStr | New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease |
| title_full_unstemmed | New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease |
| title_short | New Insight for the Diagnosis of Gastrointestinal Acute Graft-versus-Host Disease |
| title_sort | new insight for the diagnosis of gastrointestinal acute graft versus host disease |
| url | http://dx.doi.org/10.1155/2014/701013 |
| work_keys_str_mv | AT florentmalard newinsightforthediagnosisofgastrointestinalacutegraftversushostdisease AT mohamadmohty newinsightforthediagnosisofgastrointestinalacutegraftversushostdisease |