Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study
Verbal working memory (VWM) engages frontal and temporal/parietal circuits subserving the phonological loop, as well as, superior and inferior cerebellar regions which have projections from these neocortical areas. Different cerebro-cerebellar circuits may be engaged for integrating aurally- and vis...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2010-0266 |
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| author | Matthew P. Kirschen S. H. Annabel Chen John E. Desmond |
| author_facet | Matthew P. Kirschen S. H. Annabel Chen John E. Desmond |
| author_sort | Matthew P. Kirschen |
| collection | DOAJ |
| description | Verbal working memory (VWM) engages frontal and temporal/parietal circuits subserving the phonological loop, as well as, superior and inferior cerebellar regions which have projections from these neocortical areas. Different cerebro-cerebellar circuits may be engaged for integrating aurally- and visually-presented information for VWM. The present fMRI study investigated load (2, 4, or 6 letters) and modality (auditory and visual) dependent cerebro-cerebellar VWM activation using a Sternberg task. FMRI revealed modality-independent activations in left frontal (BA 6/9/44), insular, cingulate (BA 32), and bilateral inferior parietal/supramarginal (BA 40) regions, as well as in bilateral superior (HVI) and right inferior (HVIII) cerebellar regions. Visual presentation evoked prominent activations in right superior (HVI/CrusI) cerebellum, bilateral occipital (BA19) and left parietal (BA7/40) cortex while auditory presentation showed robust activations predominately in bilateral temporal regions (BA21/22). In the cerebellum, we noted a visual to auditory emphasis of function progressing from superior to inferior and from lateral to medial regions. These results extend our previous findings of fMRI activation in cerebro-cerebellar networks during VWM, and demonstrate both modality dependent commonalities and differences in activations with increasing memory load. |
| format | Article |
| id | doaj-art-0fd7856bc3074bbf9b7c23c2407b88fd |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-0fd7856bc3074bbf9b7c23c2407b88fd2025-02-03T01:26:37ZengWileyBehavioural Neurology0953-41801875-85842010-01-01231-2516310.3233/BEN-2010-0266Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI StudyMatthew P. Kirschen0S. H. Annabel Chen1John E. Desmond2Department of Radiology and Stanford University School of Medicine, Stanford, CA, USADepartment and Graduate Institute of Psychology, National Taiwan University, Taipei, TaiwanDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USAVerbal working memory (VWM) engages frontal and temporal/parietal circuits subserving the phonological loop, as well as, superior and inferior cerebellar regions which have projections from these neocortical areas. Different cerebro-cerebellar circuits may be engaged for integrating aurally- and visually-presented information for VWM. The present fMRI study investigated load (2, 4, or 6 letters) and modality (auditory and visual) dependent cerebro-cerebellar VWM activation using a Sternberg task. FMRI revealed modality-independent activations in left frontal (BA 6/9/44), insular, cingulate (BA 32), and bilateral inferior parietal/supramarginal (BA 40) regions, as well as in bilateral superior (HVI) and right inferior (HVIII) cerebellar regions. Visual presentation evoked prominent activations in right superior (HVI/CrusI) cerebellum, bilateral occipital (BA19) and left parietal (BA7/40) cortex while auditory presentation showed robust activations predominately in bilateral temporal regions (BA21/22). In the cerebellum, we noted a visual to auditory emphasis of function progressing from superior to inferior and from lateral to medial regions. These results extend our previous findings of fMRI activation in cerebro-cerebellar networks during VWM, and demonstrate both modality dependent commonalities and differences in activations with increasing memory load.http://dx.doi.org/10.3233/BEN-2010-0266 |
| spellingShingle | Matthew P. Kirschen S. H. Annabel Chen John E. Desmond Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study Behavioural Neurology |
| title | Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study |
| title_full | Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study |
| title_fullStr | Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study |
| title_full_unstemmed | Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study |
| title_short | Modality Specific Cerebro-Cerebellar Activations in Verbal Working Memory: An fMRI Study |
| title_sort | modality specific cerebro cerebellar activations in verbal working memory an fmri study |
| url | http://dx.doi.org/10.3233/BEN-2010-0266 |
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