Basal Cell Carcinoma in Type 2 Segmental Darier's Disease
Background. Darier's disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization. DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygotic condition (Vázquez et al., 2002). Clinical features...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/839561 |
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| author | Lynne Robertson Maxwell B. Sauder |
| author_facet | Lynne Robertson Maxwell B. Sauder |
| author_sort | Lynne Robertson |
| collection | DOAJ |
| description | Background. Darier's disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization. DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygotic condition (Vázquez et al., 2002). Clinical features of DD include greasy, warty papules and plaques on seborrheic areas, dystrophic nails, palmo-plantar pits, and papules on the dorsum of the hands and feet. Objective. We report a case of basal cell carcinoma developing in a patient with type 2 segmental DD. Conclusion. According to the current literature, Type 2 segmental disease is a rare presentation of Darier's disease with only 8 previous cases reported to date. In addition, nonmelanoma skin cancer (NMSC) arising from DD is rarely reported; however, there may be an association between DD and risk of carcinogenesis. |
| format | Article |
| id | doaj-art-0fd4040359994af7a2dfcf59bd3b255d |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-0fd4040359994af7a2dfcf59bd3b255d2025-02-03T05:44:28ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/839561839561Basal Cell Carcinoma in Type 2 Segmental Darier's DiseaseLynne Robertson0Maxwell B. Sauder1Division of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, CanadaDivision of Dermatology, Department of Medicine, University of Ottawa, Ottawa, ON, CanadaBackground. Darier's disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization. DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygotic condition (Vázquez et al., 2002). Clinical features of DD include greasy, warty papules and plaques on seborrheic areas, dystrophic nails, palmo-plantar pits, and papules on the dorsum of the hands and feet. Objective. We report a case of basal cell carcinoma developing in a patient with type 2 segmental DD. Conclusion. According to the current literature, Type 2 segmental disease is a rare presentation of Darier's disease with only 8 previous cases reported to date. In addition, nonmelanoma skin cancer (NMSC) arising from DD is rarely reported; however, there may be an association between DD and risk of carcinogenesis.http://dx.doi.org/10.1155/2012/839561 |
| spellingShingle | Lynne Robertson Maxwell B. Sauder Basal Cell Carcinoma in Type 2 Segmental Darier's Disease Journal of Skin Cancer |
| title | Basal Cell Carcinoma in Type 2 Segmental Darier's Disease |
| title_full | Basal Cell Carcinoma in Type 2 Segmental Darier's Disease |
| title_fullStr | Basal Cell Carcinoma in Type 2 Segmental Darier's Disease |
| title_full_unstemmed | Basal Cell Carcinoma in Type 2 Segmental Darier's Disease |
| title_short | Basal Cell Carcinoma in Type 2 Segmental Darier's Disease |
| title_sort | basal cell carcinoma in type 2 segmental darier s disease |
| url | http://dx.doi.org/10.1155/2012/839561 |
| work_keys_str_mv | AT lynnerobertson basalcellcarcinomaintype2segmentaldariersdisease AT maxwellbsauder basalcellcarcinomaintype2segmentaldariersdisease |