Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice
Peripheral nerve injury leads to severe neuropathic pain. Previous studies have highlighted the beneficial effects of physical exercise on alleviating neuropathic pain. Exercise regulating transforming growth factor-β1 (TGF-β1) can improve several diseases and relieve neuropathic pain induced by per...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/7382327 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308375049830400 |
|---|---|
| author | Xinzheng Sun Chenghao Wang Junqi Wu Xiaoke Chen Hui He |
| author_facet | Xinzheng Sun Chenghao Wang Junqi Wu Xiaoke Chen Hui He |
| author_sort | Xinzheng Sun |
| collection | DOAJ |
| description | Peripheral nerve injury leads to severe neuropathic pain. Previous studies have highlighted the beneficial effects of physical exercise on alleviating neuropathic pain. Exercise regulating transforming growth factor-β1 (TGF-β1) can improve several diseases and relieve neuropathic pain induced by peripheral nerve injury. Here, we investigated whether exercise could alleviate neuropathic pain by modulating TGF-β1 expression. We assessed mechanical and cold pain behavior and conducted molecular evaluation of the spinal cord. We found that spared nerve injury (SNI) led to mechanical and cold allodynia in the hind paw, elevated the expression of latency-associated peptide- (LAP-) TGF-β1, and activated astroglial in the spinal cord. Exercise decreases allodynia, astroglial activation, and LAP-TGF-β1 in SNI mice. Intrathecal injection of a TGF-type I receptor inhibitor attenuated exercise analgesia and enhanced astroglial activation. These findings demonstrate that exercise induces analgesia by promoting TGF-β1 activation and inhibiting astrogliosis. Our study reveals a new underlying mechanism for exercise-attenuated neuropathic pain in the maintenance stage of neuropathic pain after nerve injury. |
| format | Article |
| id | doaj-art-0fd245d6f03043eb8b46f8356d69cf85 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0fd245d6f03043eb8b46f8356d69cf852025-08-20T03:54:29ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/7382327Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury MiceXinzheng Sun0Chenghao Wang1Junqi Wu2Xiaoke Chen3Hui He4School of Sports ScienceSchool of Sports ScienceSchool of Sports ScienceSchool of Sports ScienceChina Institute of Sports and HealthPeripheral nerve injury leads to severe neuropathic pain. Previous studies have highlighted the beneficial effects of physical exercise on alleviating neuropathic pain. Exercise regulating transforming growth factor-β1 (TGF-β1) can improve several diseases and relieve neuropathic pain induced by peripheral nerve injury. Here, we investigated whether exercise could alleviate neuropathic pain by modulating TGF-β1 expression. We assessed mechanical and cold pain behavior and conducted molecular evaluation of the spinal cord. We found that spared nerve injury (SNI) led to mechanical and cold allodynia in the hind paw, elevated the expression of latency-associated peptide- (LAP-) TGF-β1, and activated astroglial in the spinal cord. Exercise decreases allodynia, astroglial activation, and LAP-TGF-β1 in SNI mice. Intrathecal injection of a TGF-type I receptor inhibitor attenuated exercise analgesia and enhanced astroglial activation. These findings demonstrate that exercise induces analgesia by promoting TGF-β1 activation and inhibiting astrogliosis. Our study reveals a new underlying mechanism for exercise-attenuated neuropathic pain in the maintenance stage of neuropathic pain after nerve injury.http://dx.doi.org/10.1155/2022/7382327 |
| spellingShingle | Xinzheng Sun Chenghao Wang Junqi Wu Xiaoke Chen Hui He Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice Neural Plasticity |
| title | Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice |
| title_full | Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice |
| title_fullStr | Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice |
| title_full_unstemmed | Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice |
| title_short | Effect of TGF-β1-Mediated Exercise Analgesia in Spared Nerve Injury Mice |
| title_sort | effect of tgf β1 mediated exercise analgesia in spared nerve injury mice |
| url | http://dx.doi.org/10.1155/2022/7382327 |
| work_keys_str_mv | AT xinzhengsun effectoftgfb1mediatedexerciseanalgesiainsparednerveinjurymice AT chenghaowang effectoftgfb1mediatedexerciseanalgesiainsparednerveinjurymice AT junqiwu effectoftgfb1mediatedexerciseanalgesiainsparednerveinjurymice AT xiaokechen effectoftgfb1mediatedexerciseanalgesiainsparednerveinjurymice AT huihe effectoftgfb1mediatedexerciseanalgesiainsparednerveinjurymice |