Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts
The present study aimed to investigate the phytochemical composition of Mentha × piperita L. (MP) and Lavandula angustifolia Mill. (LA) extracts in terms of hydroxycinnamic acid (HCAs) content, in particular, caffeic (CA), p-cumaric (CU), ferulic (FE), and rosmarinic (RS) acids using LC-MS. Also, th...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/2678924 |
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| author | Ersilia Alexa Corina Danciu Isidora Radulov Diana Obistioiu Renata Maria Sumalan Adriana Morar Cristina Adriana Dehelean |
| author_facet | Ersilia Alexa Corina Danciu Isidora Radulov Diana Obistioiu Renata Maria Sumalan Adriana Morar Cristina Adriana Dehelean |
| author_sort | Ersilia Alexa |
| collection | DOAJ |
| description | The present study aimed to investigate the phytochemical composition of Mentha × piperita L. (MP) and Lavandula angustifolia Mill. (LA) extracts in terms of hydroxycinnamic acid (HCAs) content, in particular, caffeic (CA), p-cumaric (CU), ferulic (FE), and rosmarinic (RS) acids using LC-MS. Also, the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 and MDA-MB-231) using the MTT assay were tested. The extracts were prepared using aromatic water which resulted from the extraction of oils from plants as extraction medium, with/without acid. The results showed that RS and FE represent the majority of HCAs compounds; the highest content of FE is found in LA (7.47 mg·g–1d.m.), and the maximum content of RS in MP (6.36 mg·g–1d.m.). Regarding the antimicrobial effect against Staphylococcus aureus, the two extracts showed a simulative role on the growth rate of Staphyloccocus aureus, but a slightly inhibitory effect (69.12%) can be attributed to the acidic environment. In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 μg·mL–1, the tested extracts present a weak antiproliferative effect. |
| format | Article |
| id | doaj-art-0fc5923d801d403195cfdcf1d97408d9 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-0fc5923d801d403195cfdcf1d97408d92025-02-03T01:26:38ZengWileyAnalytical Cellular Pathology2210-71772210-71852018-01-01201810.1155/2018/26789242678924Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. ExtractsErsilia Alexa0Corina Danciu1Isidora Radulov2Diana Obistioiu3Renata Maria Sumalan4Adriana Morar5Cristina Adriana Dehelean6Banat’s University of Agricultural Sciences and Veterinary Medicine, “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300645 Timişoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, Eftimie Murgu Square No. 2, 300041 Timişoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300645 Timişoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300645 Timişoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300645 Timişoara, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, “King Michael I of Romania” from Timisoara, Calea Aradului No. 119, 300645 Timişoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, Eftimie Murgu Square No. 2, 300041 Timişoara, RomaniaThe present study aimed to investigate the phytochemical composition of Mentha × piperita L. (MP) and Lavandula angustifolia Mill. (LA) extracts in terms of hydroxycinnamic acid (HCAs) content, in particular, caffeic (CA), p-cumaric (CU), ferulic (FE), and rosmarinic (RS) acids using LC-MS. Also, the in vitro antimicrobial effect against Staphylococcus aureus and the antiproliferative activity against two cancerous cell lines (A375 and MDA-MB-231) using the MTT assay were tested. The extracts were prepared using aromatic water which resulted from the extraction of oils from plants as extraction medium, with/without acid. The results showed that RS and FE represent the majority of HCAs compounds; the highest content of FE is found in LA (7.47 mg·g–1d.m.), and the maximum content of RS in MP (6.36 mg·g–1d.m.). Regarding the antimicrobial effect against Staphylococcus aureus, the two extracts showed a simulative role on the growth rate of Staphyloccocus aureus, but a slightly inhibitory effect (69.12%) can be attributed to the acidic environment. In terms of biological activity against MDA-MB-231 breast carcinoma cell line, and A375 human melanoma cell line, at the highest employed concentration, 150 μg·mL–1, the tested extracts present a weak antiproliferative effect.http://dx.doi.org/10.1155/2018/2678924 |
| spellingShingle | Ersilia Alexa Corina Danciu Isidora Radulov Diana Obistioiu Renata Maria Sumalan Adriana Morar Cristina Adriana Dehelean Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts Analytical Cellular Pathology |
| title | Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts |
| title_full | Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts |
| title_fullStr | Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts |
| title_full_unstemmed | Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts |
| title_short | Phytochemical Screening and Biological Activity of Mentha × piperita L. and Lavandula angustifolia Mill. Extracts |
| title_sort | phytochemical screening and biological activity of mentha piperita l and lavandula angustifolia mill extracts |
| url | http://dx.doi.org/10.1155/2018/2678924 |
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