Sulphasalazine-Induced Pseudomembranous Colitis
An 18-year-old female with ankylosing spondylitis developed fever, abdominal pain and diarrhea on two occasions after starting sulphasalazine therapy. Flexible sigmoidoscopy revealed pseudomembranous colitis; fecal cultures were positive for Clostridium difficile; and C difficile toxin assay was pos...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1991-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1991/420864 |
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| _version_ | 1832562998482305024 |
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| author | Hugh J Freeman Urs P Steinbrecher WC Peter Kwan Stephanie Ensworth |
| author_facet | Hugh J Freeman Urs P Steinbrecher WC Peter Kwan Stephanie Ensworth |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | An 18-year-old female with ankylosing spondylitis developed fever, abdominal pain and diarrhea on two occasions after starting sulphasalazine therapy. Flexible sigmoidoscopy revealed pseudomembranous colitis; fecal cultures were positive for Clostridium difficile; and C difficile toxin assay was positive. Despite the frequent use of sulphasalazine in the management of inflammatory bowel disease, this complication has been apparently rare. Clinicians should be wary of the onset of diarrhea in patients receiving sulphasalazine, whether for inflammatory bowel disease or other conditions. |
| format | Article |
| id | doaj-art-0fbd223d5d8644a99b6114e1a4080317 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1991-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-0fbd223d5d8644a99b6114e1a40803172025-02-03T01:21:16ZengWileyCanadian Journal of Gastroenterology0835-79001991-01-015516717010.1155/1991/420864Sulphasalazine-Induced Pseudomembranous ColitisHugh J Freeman0Urs P Steinbrecher1WC Peter Kwan2Stephanie Ensworth3Department of Medicine (Gastroenterology and Rheumatology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology and Rheumatology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology and Rheumatology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine (Gastroenterology and Rheumatology), University Hospital and University of British Columbia, Vancouver, British Columbia, CanadaAn 18-year-old female with ankylosing spondylitis developed fever, abdominal pain and diarrhea on two occasions after starting sulphasalazine therapy. Flexible sigmoidoscopy revealed pseudomembranous colitis; fecal cultures were positive for Clostridium difficile; and C difficile toxin assay was positive. Despite the frequent use of sulphasalazine in the management of inflammatory bowel disease, this complication has been apparently rare. Clinicians should be wary of the onset of diarrhea in patients receiving sulphasalazine, whether for inflammatory bowel disease or other conditions.http://dx.doi.org/10.1155/1991/420864 |
| spellingShingle | Hugh J Freeman Urs P Steinbrecher WC Peter Kwan Stephanie Ensworth Sulphasalazine-Induced Pseudomembranous Colitis Canadian Journal of Gastroenterology |
| title | Sulphasalazine-Induced Pseudomembranous Colitis |
| title_full | Sulphasalazine-Induced Pseudomembranous Colitis |
| title_fullStr | Sulphasalazine-Induced Pseudomembranous Colitis |
| title_full_unstemmed | Sulphasalazine-Induced Pseudomembranous Colitis |
| title_short | Sulphasalazine-Induced Pseudomembranous Colitis |
| title_sort | sulphasalazine induced pseudomembranous colitis |
| url | http://dx.doi.org/10.1155/1991/420864 |
| work_keys_str_mv | AT hughjfreeman sulphasalazineinducedpseudomembranouscolitis AT urspsteinbrecher sulphasalazineinducedpseudomembranouscolitis AT wcpeterkwan sulphasalazineinducedpseudomembranouscolitis AT stephanieensworth sulphasalazineinducedpseudomembranouscolitis |