Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation
Hair cells (HCs) are the sensory preceptor cells in the inner ear, which play an important role in hearing and balance. The HCs of organ of Corti are susceptible to noise, ototoxic drugs, and infections, thus resulting in permanent hearing loss. Recent approaches of HCs regeneration provide new dire...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/2523458 |
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| _version_ | 1832551994289553408 |
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| author | Xiaoling Lu Yilai Shu Mingliang Tang Huawei Li |
| author_facet | Xiaoling Lu Yilai Shu Mingliang Tang Huawei Li |
| author_sort | Xiaoling Lu |
| collection | DOAJ |
| description | Hair cells (HCs) are the sensory preceptor cells in the inner ear, which play an important role in hearing and balance. The HCs of organ of Corti are susceptible to noise, ototoxic drugs, and infections, thus resulting in permanent hearing loss. Recent approaches of HCs regeneration provide new directions for finding the treatment of sensor neural deafness. To have normal hearing function, the regenerated HCs must be reinnervated by nerve fibers and reform ribbon synapse with the dendrite of spiral ganglion neuron through nerve regeneration. In this review, we discuss the research progress in HC regeneration, the synaptic plasticity, and the reinnervation of new regenerated HCs in mammalian inner ear. |
| format | Article |
| id | doaj-art-0fb45bf7fb964030a095c840a87fd37a |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0fb45bf7fb964030a095c840a87fd37a2025-02-03T05:59:45ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/25234582523458Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse ReformationXiaoling Lu0Yilai Shu1Mingliang Tang2Huawei Li3Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaOtorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, ChinaOtorhinolaryngology Department of Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaHair cells (HCs) are the sensory preceptor cells in the inner ear, which play an important role in hearing and balance. The HCs of organ of Corti are susceptible to noise, ototoxic drugs, and infections, thus resulting in permanent hearing loss. Recent approaches of HCs regeneration provide new directions for finding the treatment of sensor neural deafness. To have normal hearing function, the regenerated HCs must be reinnervated by nerve fibers and reform ribbon synapse with the dendrite of spiral ganglion neuron through nerve regeneration. In this review, we discuss the research progress in HC regeneration, the synaptic plasticity, and the reinnervation of new regenerated HCs in mammalian inner ear.http://dx.doi.org/10.1155/2016/2523458 |
| spellingShingle | Xiaoling Lu Yilai Shu Mingliang Tang Huawei Li Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation Neural Plasticity |
| title | Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation |
| title_full | Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation |
| title_fullStr | Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation |
| title_full_unstemmed | Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation |
| title_short | Mammalian Cochlear Hair Cell Regeneration and Ribbon Synapse Reformation |
| title_sort | mammalian cochlear hair cell regeneration and ribbon synapse reformation |
| url | http://dx.doi.org/10.1155/2016/2523458 |
| work_keys_str_mv | AT xiaolinglu mammaliancochlearhaircellregenerationandribbonsynapsereformation AT yilaishu mammaliancochlearhaircellregenerationandribbonsynapsereformation AT mingliangtang mammaliancochlearhaircellregenerationandribbonsynapsereformation AT huaweili mammaliancochlearhaircellregenerationandribbonsynapsereformation |