KLF4 promotes cisplatin resistance by activating mTORC1 signaling in ovarian cancer

KLF4 promotes cisplatin resistance by activating mTORC1 signaling in ovarian cancer

Abstract Ovarian cancer (OC) is a highly fatal gynecological malignancy worldwide, and cisplatin (CDDP) is commonly used as an initial chemotherapy treatment for OC. Nonetheless, most patients ultimately face recurrence because of resistance to cisplatin. Therefore, it is imperative to investigate t...

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Bibliographic Details
Main Authors: Wanzhen Zhou, Huixian Huang, Yincheng Teng, Rong Hua, Yan Hu, Xiao Li
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Discover Oncology
Subjects:
Ovarian cancer
KLF4
Cisplatin resistance
mTORC1 pathway
Online Access:https://doi.org/10.1007/s12672-024-01576-y
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