Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain

Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain

Background. This study aimed to investigate the use of human bone marrow mesenchymal stem cells (hBMSCs) genetically engineered with the human proenkephalin (hPPE) gene to treat bone cancer pain (BCP) in a rat model. Methods. Primary cultured hBMSCs were passaged and modified with hPPE, and the cell...

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Bibliographic Details
Main Authors: Yi Sun, Yuke Tian, Haifeng Li, Dengwen Zhang, Qiang Sun
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Pain Research and Management
Online Access:http://dx.doi.org/10.1155/2017/7346103
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