Lymphocyte Subpopulations in Pulmonary Tuberculosis Patients
Protection against Mycobacterium tuberculosis is based on cell-mediated immunity, most importantly involving CD4+ and CD8+ T-cell subsets. The aim of this study was to evaluate CD4+ and CD8+ T-cell profiles and CD19+ and CD3-CD(16+56)+ populations in patients with pulmonary tuberculosis. CD4+ and CD...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/89070 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Protection against Mycobacterium
tuberculosis is based on cell-mediated immunity, most importantly
involving CD4+ and CD8+ T-cell subsets. The aim of this study was to evaluate CD4+
and CD8+ T-cell profiles and CD19+ and CD3-CD(16+56)+ populations in patients with pulmonary
tuberculosis. CD4+ and CD8+ T cells, B-lymphocytes, and natural killer (NK) cells were evaluated in 75
active (APTB) and 25 inactive (IPTB) pulmonary tuberculosis cases
and 20 healthy subjects (HCs). The results were compared at
different stages of antituberculosis treatment in the APTB
patients and also according to X-ray findings in the newly
diagnosed APTB patients. The percentages of
CD4+ T cells were significantly lower (P<.01) and those of
CD3-CD(16+56)+ cells were significantly higher (P<.01)
in APTB patients than in HCs. CD8+ T cells were significantly
decreased (P<.05), and CD3-CD(16+56)+ cells were
significantly increased (P<.01), in IPTB patients compared to
HCs. The percentages of CD4+, CD8+, CD3-CD19+, and CD3-CD(16+56)+ cells showed no differences at
different times of the antituberculosis regimen, and different
stages of newly diagnosed APTB patients. APTB
patients have a reduced percentage of circulating CD4+ T cells and an increased percentage of NK cells compared with
healthy individuals. These cells could play important roles in the
immune response to M tuberculosis infection. |
|---|---|
| ISSN: | 0962-9351 1466-1861 |