Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro)
In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP), prostat...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/218675 |
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| author | Zahraa Salim M. Al-Garawi Ivan Hameed R. Tomi Ali Hussein R. Al-Daraji |
| author_facet | Zahraa Salim M. Al-Garawi Ivan Hameed R. Tomi Ali Hussein R. Al-Daraji |
| author_sort | Zahraa Salim M. Al-Garawi |
| collection | DOAJ |
| description | In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3 and 5.5×10-4 M) and activator effect at low concentration (5.5×10-5 M) while it was exhibits as activator on PAP activity. |
| format | Article |
| id | doaj-art-0f973756fa68438081587de4ab8e2372 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-0f973756fa68438081587de4ab8e23722025-02-03T06:44:51ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-019296296910.1155/2012/218675Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro)Zahraa Salim M. Al-Garawi0Ivan Hameed R. Tomi1Ali Hussein R. Al-Daraji2Department of Chemistry, College of Sciences, University of Al-Mustansiriya, Baghdad, IraqDepartment of Chemistry, College of Sciences, University of Al-Mustansiriya, Baghdad, IraqDepartment of Chemistry, College of Sciences, University of Al-Mustansiriya, Baghdad, IraqIn this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3 and 5.5×10-4 M) and activator effect at low concentration (5.5×10-5 M) while it was exhibits as activator on PAP activity.http://dx.doi.org/10.1155/2012/218675 |
| spellingShingle | Zahraa Salim M. Al-Garawi Ivan Hameed R. Tomi Ali Hussein R. Al-Daraji Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro) E-Journal of Chemistry |
| title | Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro) |
| title_full | Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro) |
| title_fullStr | Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro) |
| title_full_unstemmed | Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro) |
| title_short | Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro) |
| title_sort | synthesis and characterization of new amino acid schiff bases and studies their effects on the activity of acp pap and npa enzymes in vitro |
| url | http://dx.doi.org/10.1155/2012/218675 |
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