Prognostic and predictive significance of osteopontin in malignant neoplasms
Osteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes. This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the re...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2021-07-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/352 |
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| author | E. Yu. Zubareva M. A. Senchukova |
| author_facet | E. Yu. Zubareva M. A. Senchukova |
| author_sort | E. Yu. Zubareva |
| collection | DOAJ |
| description | Osteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes. This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the regulation of epithelial-mesenchymal transition, angiogenesis, and the body’s immune response to the tumor. The article considers the currently known mechanisms by which osteopontin affects to the survival, mobility and invasion of tumor cells, to tumor sensitivity to drug treatment, as well as the prospects for a integrated study of the predictive significance of osteopontin, markers of hypoxia, angiogenesis, epithelial- mesenchymal transition, and immunological tolerance. |
| format | Article |
| id | doaj-art-0f927f30b4a04099a10ea94de16549bb |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2021-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-0f927f30b4a04099a10ea94de16549bb2025-08-20T03:22:00ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872021-07-0182232810.17650/2313-805X-2021-8-2-23-28207Prognostic and predictive significance of osteopontin in malignant neoplasmsE. Yu. Zubareva0M. A. Senchukova1Orenburg Regional Clinical Oncological Dispensary; Orenburg State Medical UniversityOrenburg Regional Clinical Oncological Dispensary; Orenburg State Medical UniversityOsteopontin is an extracellular matrix protein which is produced by different types of cells and plays an important functional role in many biological processes. This review discusses the main functions of osteopontin, its role in the progression and chemoresistance of malignant neoplasms, in the regulation of epithelial-mesenchymal transition, angiogenesis, and the body’s immune response to the tumor. The article considers the currently known mechanisms by which osteopontin affects to the survival, mobility and invasion of tumor cells, to tumor sensitivity to drug treatment, as well as the prospects for a integrated study of the predictive significance of osteopontin, markers of hypoxia, angiogenesis, epithelial- mesenchymal transition, and immunological tolerance.https://umo.abvpress.ru/jour/article/view/352osteopontinprogression of malignant neoplasmsinvasionmetastasisepithelial-mesenchymal transitionimmunological tolerancehypoxiaangiogenesischemoresistance |
| spellingShingle | E. Yu. Zubareva M. A. Senchukova Prognostic and predictive significance of osteopontin in malignant neoplasms Успехи молекулярной онкологии osteopontin progression of malignant neoplasms invasion metastasis epithelial-mesenchymal transition immunological tolerance hypoxia angiogenesis chemoresistance |
| title | Prognostic and predictive significance of osteopontin in malignant neoplasms |
| title_full | Prognostic and predictive significance of osteopontin in malignant neoplasms |
| title_fullStr | Prognostic and predictive significance of osteopontin in malignant neoplasms |
| title_full_unstemmed | Prognostic and predictive significance of osteopontin in malignant neoplasms |
| title_short | Prognostic and predictive significance of osteopontin in malignant neoplasms |
| title_sort | prognostic and predictive significance of osteopontin in malignant neoplasms |
| topic | osteopontin progression of malignant neoplasms invasion metastasis epithelial-mesenchymal transition immunological tolerance hypoxia angiogenesis chemoresistance |
| url | https://umo.abvpress.ru/jour/article/view/352 |
| work_keys_str_mv | AT eyuzubareva prognosticandpredictivesignificanceofosteopontininmalignantneoplasms AT masenchukova prognosticandpredictivesignificanceofosteopontininmalignantneoplasms |