Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants
Aim. To assess the association of cardiovascular risk factors with various vascular aging phenotypes using the St. Petersburg population sample as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study.Material and methods. The cur...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2021-09-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2970 |
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| author | O. P. Rotar M. A. Boiarinova K. M. Tolkunova E. V. Moguchaia A. S. Alievа A. V. Orlov E. P. Kolesova A. M. Erina D. A. Usoltsev V. N. Solntsev E. I. Baranova A. O. Konradi E. V. Shlyakhto |
| author_facet | O. P. Rotar M. A. Boiarinova K. M. Tolkunova E. V. Moguchaia A. S. Alievа A. V. Orlov E. P. Kolesova A. M. Erina D. A. Usoltsev V. N. Solntsev E. I. Baranova A. O. Konradi E. V. Shlyakhto |
| author_sort | O. P. Rotar |
| collection | DOAJ |
| description | Aim. To assess the association of cardiovascular risk factors with various vascular aging phenotypes using the St. Petersburg population sample as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study.Material and methods. The current analysis, performed within the ESSE-RF multicenter observational study, included 1600 St. Petersburg residents. The participants filled out a questionnaire to assess risk factors. In addition, blood biochemical parameters, anthropometric characteristics, and blood pressure were evaluated. Pulse wave velocity (PWV) was assessed by applanation tonometry using the SphygmoCor device (AtCor, Australia) in 524 people. For analysis, 485 participants without prior cardiovascular events were selected. PWV ≤10 percentile of PWV for healthy individuals in each age group was considered as the criterion for supernormal vascular aging (SUPERNOVA) phenotype, the PWV ≥90 percentile — early vascular aging (EVA), the PWV of 10-90 percentile — normal vascular aging (NVA).Results. The prevalence of SUPERNOVA phenotype was 9,7%, EVA — 18,8%, NVA — 71,5%. Patients with EVA phenotype were more likely to have HTN (60,4%) in comparison with those with SUPERNOVA phenotype (17%) and, less likely — high physical activity (39,6 vs 53,2%). Obesity, hyperglycemia, insulin resistance, hypercholesterolemia, dyslipoproteinemia, and excessive alcohol consumption were significantly less common in participants with SUPERNOVA phenotype compared with those with EVA phenotype.Conclusion. In addition to HTN and dyslipoproteinemia, a significant predictor of premature aging was the cumulative effect of obesity, insulin resistance and hypertriglyceridemia. Among behavioral risk factors, higher physical activity and adequate alcohol consumption were factors associated with supernormal aging. |
| format | Article |
| id | doaj-art-0f8917dbe5d04484bfba7e44b50dee8b |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-0f8917dbe5d04484bfba7e44b50dee8b2025-08-20T03:57:17Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-09-0120510.15829/1728-8800-2021-29702303Vascular aging phenotypes in Russian population — biological, social, and behavioral determinantsO. P. Rotar0M. A. Boiarinova1K. M. Tolkunova2E. V. Moguchaia3A. S. Alievа4A. V. Orlov5E. P. Kolesova6A. M. Erina7D. A. Usoltsev8V. N. Solntsev9E. I. Baranova10A. O. Konradi11E. V. Shlyakhto12Almazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research CenterSanatorium “Rodina”Almazov National Medical Research CenterAlmazov National Medical Research CenterAlmazov National Medical Research Center; Saint Petersburg National Research University of Information Technologies, Mechanics and OpticsAlmazov National Medical Research CenterAlmazov National Medical Research Center; First Pavlov State Medical UniversityAlmazov National Medical Research Center; Saint Petersburg National Research University of Information Technologies, Mechanics and OpticsAlmazov National Medical Research CenterAim. To assess the association of cardiovascular risk factors with various vascular aging phenotypes using the St. Petersburg population sample as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study.Material and methods. The current analysis, performed within the ESSE-RF multicenter observational study, included 1600 St. Petersburg residents. The participants filled out a questionnaire to assess risk factors. In addition, blood biochemical parameters, anthropometric characteristics, and blood pressure were evaluated. Pulse wave velocity (PWV) was assessed by applanation tonometry using the SphygmoCor device (AtCor, Australia) in 524 people. For analysis, 485 participants without prior cardiovascular events were selected. PWV ≤10 percentile of PWV for healthy individuals in each age group was considered as the criterion for supernormal vascular aging (SUPERNOVA) phenotype, the PWV ≥90 percentile — early vascular aging (EVA), the PWV of 10-90 percentile — normal vascular aging (NVA).Results. The prevalence of SUPERNOVA phenotype was 9,7%, EVA — 18,8%, NVA — 71,5%. Patients with EVA phenotype were more likely to have HTN (60,4%) in comparison with those with SUPERNOVA phenotype (17%) and, less likely — high physical activity (39,6 vs 53,2%). Obesity, hyperglycemia, insulin resistance, hypercholesterolemia, dyslipoproteinemia, and excessive alcohol consumption were significantly less common in participants with SUPERNOVA phenotype compared with those with EVA phenotype.Conclusion. In addition to HTN and dyslipoproteinemia, a significant predictor of premature aging was the cumulative effect of obesity, insulin resistance and hypertriglyceridemia. Among behavioral risk factors, higher physical activity and adequate alcohol consumption were factors associated with supernormal aging.https://cardiovascular.elpub.ru/jour/article/view/2970supernormal vascular agingearly vascular agingvascular stiffnesshypertensiondyslipoproteinemiaphysical activity |
| spellingShingle | O. P. Rotar M. A. Boiarinova K. M. Tolkunova E. V. Moguchaia A. S. Alievа A. V. Orlov E. P. Kolesova A. M. Erina D. A. Usoltsev V. N. Solntsev E. I. Baranova A. O. Konradi E. V. Shlyakhto Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants Кардиоваскулярная терапия и профилактика supernormal vascular aging early vascular aging vascular stiffness hypertension dyslipoproteinemia physical activity |
| title | Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants |
| title_full | Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants |
| title_fullStr | Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants |
| title_full_unstemmed | Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants |
| title_short | Vascular aging phenotypes in Russian population — biological, social, and behavioral determinants |
| title_sort | vascular aging phenotypes in russian population biological social and behavioral determinants |
| topic | supernormal vascular aging early vascular aging vascular stiffness hypertension dyslipoproteinemia physical activity |
| url | https://cardiovascular.elpub.ru/jour/article/view/2970 |
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