Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo
The binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application. One promising avenue that is currently explored based on the specificity and affinity of aptamers is the application of apta...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.1155/2017/3712070 |
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| author | Mawethu Pascoe Bilibana Marimuthu Citartan Tzi Shien Yeoh Timofey S. Rozhdestvensky Thean-Hock Tang |
| author_facet | Mawethu Pascoe Bilibana Marimuthu Citartan Tzi Shien Yeoh Timofey S. Rozhdestvensky Thean-Hock Tang |
| author_sort | Mawethu Pascoe Bilibana |
| collection | DOAJ |
| description | The binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application. One promising avenue that is currently explored based on the specificity and affinity of aptamers is the application of aptamers in the decontamination assays. Aptamers have been successfully harnessed as the decontamination agents to remove contaminants from the environment and to decontaminate infectious elements. The reversible denaturation property inherent in aptamers enables the repeated usage of aptamers, which can immensely save the cost of decontamination. Analogous to the point-of-care diagnostics, there is no doubt that aptamers can also be deployed in the point-of-care aptamer-based decontamination assay, whereby decontamination can be performed anywhere and anytime for instantaneous decision-making. It is also prophesied that aptamers can also serve more than as a decontaminant, probably as a tool to capture and kill hazardous elements, particularly pathogenic agents. |
| format | Article |
| id | doaj-art-0f8855baafb8475fbd984c30b78243bf |
| institution | Kabale University |
| issn | 2090-0201 2090-021X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-0f8855baafb8475fbd984c30b78243bf2025-02-03T06:48:06ZengWileyJournal of Nucleic Acids2090-02012090-021X2017-01-01201710.1155/2017/37120703712070Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In VivoMawethu Pascoe Bilibana0Marimuthu Citartan1Tzi Shien Yeoh2Timofey S. Rozhdestvensky3Thean-Hock Tang4Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, MalaysiaAdvanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, MalaysiaAdvanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, MalaysiaMedical Faculty (TRAM), University of Muenster, Von-Esmarch-Str. 56, 48149 Münster, GermanyAdvanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, MalaysiaThe binding specificity and affinity of aptamers have long been harnessed as the key elements in the development of aptamer-based assays, particularly aptasensing application. One promising avenue that is currently explored based on the specificity and affinity of aptamers is the application of aptamers in the decontamination assays. Aptamers have been successfully harnessed as the decontamination agents to remove contaminants from the environment and to decontaminate infectious elements. The reversible denaturation property inherent in aptamers enables the repeated usage of aptamers, which can immensely save the cost of decontamination. Analogous to the point-of-care diagnostics, there is no doubt that aptamers can also be deployed in the point-of-care aptamer-based decontamination assay, whereby decontamination can be performed anywhere and anytime for instantaneous decision-making. It is also prophesied that aptamers can also serve more than as a decontaminant, probably as a tool to capture and kill hazardous elements, particularly pathogenic agents.http://dx.doi.org/10.1155/2017/3712070 |
| spellingShingle | Mawethu Pascoe Bilibana Marimuthu Citartan Tzi Shien Yeoh Timofey S. Rozhdestvensky Thean-Hock Tang Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo Journal of Nucleic Acids |
| title | Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo |
| title_full | Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo |
| title_fullStr | Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo |
| title_full_unstemmed | Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo |
| title_short | Aptamers as the Agent in Decontamination Assays (Apta-Decontamination Assays): From the Environment to the Potential Application In Vivo |
| title_sort | aptamers as the agent in decontamination assays apta decontamination assays from the environment to the potential application in vivo |
| url | http://dx.doi.org/10.1155/2017/3712070 |
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