IL-17 triggers PD-L1 gene transcription in NSCLC cells via TRIM31-dependent MEF2C K63-linked polyubiquitination

IL-17 triggers PD-L1 gene transcription in NSCLC cells via TRIM31-dependent MEF2C K63-linked polyubiquitination

Abstract Background Non-small cell lung cancer (NSCLC) is a disease related to inflammation. Proinflammatory cytokines such as interleukin 17 (IL-17) can induce cancer cell proliferation, metastasis and immune escape. Although NSCLC immune escape is partly due to the interaction between PD-1 and PD-...

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Bibliographic Details
Main Authors: Shuai Ying, Ningxia Wu, Yuting Ruan, Wen Ge, Pei Ma, Tongpeng Xu, Yongqian Shu, Yingwei Wang, Wen Qiu, Chenhui Zhao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
NSCLC
IL-17
PD-L1
MEF2C
TRIM31
K63-linked polyubiquitination
Online Access:https://doi.org/10.1186/s12885-025-13473-w
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