Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study
This study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 part...
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The Japan Endocrine Society
2024-10-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/10/71_EJ23-0568/_html/-char/en |
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| author | Seiya Izumi Noriyuki Iwama Hirotaka Hamada Taku Obara Mami Ishikuro Michihiro Satoh Takahisa Murakami Masatoshi Saito Takayoshi Ohkubo Takashi Sugiyama Shinichi Kuriyama Nobuo Yaegashi Kazuhiko Hoshi Yutaka Imai Hirohito Metoki the BOSHI Study Group |
| author_facet | Seiya Izumi Noriyuki Iwama Hirotaka Hamada Taku Obara Mami Ishikuro Michihiro Satoh Takahisa Murakami Masatoshi Saito Takayoshi Ohkubo Takashi Sugiyama Shinichi Kuriyama Nobuo Yaegashi Kazuhiko Hoshi Yutaka Imai Hirohito Metoki the BOSHI Study Group |
| author_sort | Seiya Izumi |
| collection | DOAJ |
| description | This study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 participants were included in this prospective cohort study. HDP, FPG, HbA1c, and potential confounding factors were included in multiple logistic regression models. The number of HDP cases was 136 (11.5%). When FPG and HbA1c were included in the model separately, quartile 4 (Q4) of FPG (87–125 mg/dL) and HbA1c (5.2–6.3% [33–45 mmol/mol]) levels had higher odds of HDP than quartile 1. The odds ratios (ORs) were 1.334 (95% confidence interval [CI]: 1.002–1.775) for Q4 of FPG and 1.405 (95% CI: 1.051–1.878) for Q4 of HbA1c. When the participants were divided into two categories based on the cut-off value with the maximum Youden Index of FPG or HbA1c, the ORs for high FPG (≥84 mg/dL) or high HbA1c (≥5.2% [33 mmol/mol]) were 1.223 (95% CI: 1.000–1.496) and 1.392 (95% CI: 1.122–1.728), respectively. When both FPG and HbA1c were included in the model simultaneously, the statistical significance of Q4 of FPG disappeared, whereas that of HbA1c remained. In two-category models, the same results were obtained. High FPG and HbA1c levels at <24 weeks of gestation were risk factors for HDP in pregnant Japanese women. In addition, high HbA1c levels were more strongly associated with HDP than high FPG levels. |
| format | Article |
| id | doaj-art-0f86ca90add142d881bfd2a79c8290ef |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-0f86ca90add142d881bfd2a79c8290ef2025-01-22T05:22:56ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-10-01711097999310.1507/endocrj.EJ23-0568endocrjAssociations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI studySeiya Izumi0Noriyuki Iwama1Hirotaka Hamada2Taku Obara3Mami Ishikuro4Michihiro Satoh5Takahisa Murakami6Masatoshi Saito7Takayoshi Ohkubo8Takashi Sugiyama9Shinichi Kuriyama10Nobuo Yaegashi11Kazuhiko Hoshi12Yutaka Imai13Hirohito Metoki14the BOSHI Study GroupDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, JapanDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, JapanDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, JapanDivision of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Miyagi 980-8573, JapanDivision of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Miyagi 980-8573, JapanDivision of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University, Miyagi 983-8536, JapanDivision of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University, Miyagi 983-8536, JapanDepartment of Obstetrics and Gynecology, Tohoku University Hospital, Miyagi 980-8574, JapanDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo 173-8605, JapanDepartment of Obstetrics and Gynecology, Ehime University Graduate School of Medicine, Ehime 791-0295, JapanDivision of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Miyagi 980-8573, JapanDepartment of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, JapanSuzuki Memorial Hospital, Miyagi 989-2481, JapanTohoku Institute for Management of Blood Pressure, Miyagi 980-0802, JapanDivision of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University, Miyagi 983-8536, JapanThis study aimed to evaluate the associations of fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) levels at <24 weeks of gestation with hypertensive disorders of pregnancy (HDP) and compare the strengths of the associations of HDP with FPG and HbA1c levels. Totally, 1,178 participants were included in this prospective cohort study. HDP, FPG, HbA1c, and potential confounding factors were included in multiple logistic regression models. The number of HDP cases was 136 (11.5%). When FPG and HbA1c were included in the model separately, quartile 4 (Q4) of FPG (87–125 mg/dL) and HbA1c (5.2–6.3% [33–45 mmol/mol]) levels had higher odds of HDP than quartile 1. The odds ratios (ORs) were 1.334 (95% confidence interval [CI]: 1.002–1.775) for Q4 of FPG and 1.405 (95% CI: 1.051–1.878) for Q4 of HbA1c. When the participants were divided into two categories based on the cut-off value with the maximum Youden Index of FPG or HbA1c, the ORs for high FPG (≥84 mg/dL) or high HbA1c (≥5.2% [33 mmol/mol]) were 1.223 (95% CI: 1.000–1.496) and 1.392 (95% CI: 1.122–1.728), respectively. When both FPG and HbA1c were included in the model simultaneously, the statistical significance of Q4 of FPG disappeared, whereas that of HbA1c remained. In two-category models, the same results were obtained. High FPG and HbA1c levels at <24 weeks of gestation were risk factors for HDP in pregnant Japanese women. In addition, high HbA1c levels were more strongly associated with HDP than high FPG levels.https://www.jstage.jst.go.jp/article/endocrj/71/10/71_EJ23-0568/_html/-char/enfasting plasma glucosehyperglycemiaglycosylated hemoglobinhypertensive disorders of pregnancythe boshi study |
| spellingShingle | Seiya Izumi Noriyuki Iwama Hirotaka Hamada Taku Obara Mami Ishikuro Michihiro Satoh Takahisa Murakami Masatoshi Saito Takayoshi Ohkubo Takashi Sugiyama Shinichi Kuriyama Nobuo Yaegashi Kazuhiko Hoshi Yutaka Imai Hirohito Metoki the BOSHI Study Group Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study Endocrine Journal fasting plasma glucose hyperglycemia glycosylated hemoglobin hypertensive disorders of pregnancy the boshi study |
| title | Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study |
| title_full | Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study |
| title_fullStr | Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study |
| title_full_unstemmed | Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study |
| title_short | Associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy: the BOSHI study |
| title_sort | associations of fasting plasma glucose and glycosylated hemoglobin levels at less than 24 weeks of gestation with hypertensive disorders of pregnancy the boshi study |
| topic | fasting plasma glucose hyperglycemia glycosylated hemoglobin hypertensive disorders of pregnancy the boshi study |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/10/71_EJ23-0568/_html/-char/en |
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