Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells
The translation of mRNA constitutes the first step in the synthesis of a functional protein. The polypeptide chain is subsequently folded into the appropriate three-dimensional configuration and undergoes a variety of processing steps before being converted into its active form. These processing ste...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2000/198641 |
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| _version_ | 1832545555154206720 |
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| author | Gary E Wild Patrizia Papalia Mark J Ropeleski Julio Faria Alan BR Thomson |
| author_facet | Gary E Wild Patrizia Papalia Mark J Ropeleski Julio Faria Alan BR Thomson |
| author_sort | Gary E Wild |
| collection | DOAJ |
| description | The translation of mRNA constitutes the first step in the synthesis of a functional protein. The polypeptide chain is subsequently folded into the appropriate three-dimensional configuration and undergoes a variety of processing steps before being converted into its active form. These processing steps are intimately related to the cellular events that occur in the endoplasmic reticulum and Golgi compartments, and determine the sorting and transport of different proteins to their appropriate destinations within the cell. While the regulation of gene expression occurs primarily at the level of transcription, the expression of many genes can also be controlled at the level of translation. Most proteins can be regulated in response to extracellular signals. In addition, intracellular protein levels can be controlled by differential rates of protein degradation. Thus, the regulation of both the amounts and activities of intracellular proteins ultimately determines all aspects of cell behaviour. |
| format | Article |
| id | doaj-art-0f85247353e547c99ffcc5ba07d7d3f5 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-0f85247353e547c99ffcc5ba07d7d3f52025-02-03T07:25:21ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114760361610.1155/2000/198641Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic CellsGary E Wild0Patrizia Papalia1Mark J Ropeleski2Julio Faria3Alan BR Thomson4Department of Medicine, Division of Gastroenterology, McGill University Health Centre, and McGill University Inflammatory Bowel Disease Research Program, Montreal, Quebec, CanadaDepartment of Medicine, Division of Gastroenterology, McGill University Health Centre, and McGill University Inflammatory Bowel Disease Research Program, Montreal, Quebec, CanadaDepartment of Medicine, Division of Gastroenterology, McGill University Health Centre, and McGill University Inflammatory Bowel Disease Research Program, Montreal, Quebec, CanadaDepartment of Medicine, Division of Gastroenterology, McGill University Health Centre, and McGill University Inflammatory Bowel Disease Research Program, Montreal, Quebec, CanadaDepartment of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaThe translation of mRNA constitutes the first step in the synthesis of a functional protein. The polypeptide chain is subsequently folded into the appropriate three-dimensional configuration and undergoes a variety of processing steps before being converted into its active form. These processing steps are intimately related to the cellular events that occur in the endoplasmic reticulum and Golgi compartments, and determine the sorting and transport of different proteins to their appropriate destinations within the cell. While the regulation of gene expression occurs primarily at the level of transcription, the expression of many genes can also be controlled at the level of translation. Most proteins can be regulated in response to extracellular signals. In addition, intracellular protein levels can be controlled by differential rates of protein degradation. Thus, the regulation of both the amounts and activities of intracellular proteins ultimately determines all aspects of cell behaviour.http://dx.doi.org/10.1155/2000/198641 |
| spellingShingle | Gary E Wild Patrizia Papalia Mark J Ropeleski Julio Faria Alan BR Thomson Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells Canadian Journal of Gastroenterology |
| title | Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells |
| title_full | Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells |
| title_fullStr | Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells |
| title_full_unstemmed | Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells |
| title_short | Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells |
| title_sort | applications of recombinant dna technology in gastrointestinal medicine and hepatology basic paradigms of molecular cell biology part c protein synthesis and post translational processing in eukaryotic cells |
| url | http://dx.doi.org/10.1155/2000/198641 |
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