Developing a clinical prediction model to modify empirical antibiotics for non-typhoidal Salmonella bloodstream infection in children under-five in the Democratic Republic of Congo

Developing a clinical prediction model to modify empirical antibiotics for non-typhoidal Salmonella bloodstream infection in children under-five in the Democratic Republic of Congo

Abstract Background Non-typhoidal Salmonella (NTS) frequently cause bloodstream infection in children under-five in sub-Saharan Africa, particularly in malaria-endemic areas. Due to increasing drug resistance, NTS are often not covered by standard-of-care empirical antibiotics for severe febrile ill...

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Main Authors: Bieke Tack, Daniel Vita, Jules Mbuyamba, Emmanuel Ntangu, Hornela Vuvu, Immaculée Kahindo, Japhet Ngina, Aimée Luyindula, Naomie Nama, Tito Mputu, Justin Im, Hyonjin Jeon, Florian Marks, Jaan Toelen, Octavie Lunguya, Jan Jacobs, Ben Van Calster
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Infectious Diseases
Subjects:
Non-typhoidal Salmonella
Bloodstream infection
Children under-five
Clinical prediction model
Empirical antibiotics
Online Access:https://doi.org/10.1186/s12879-024-10319-x
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