Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression

Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression

Abstract Oral squamous cell carcinoma (OSCC) progresses from preneoplastic precursors via genetic and epigenetic alterations. Previous studies have focused on the treatment of terminally developed OSCC. However, the role of epigenetic regulators as therapeutic targets during the transition from pren...

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Main Authors: Amit Kumar Chakraborty, Rajnikant Dilip Raut, Kisa Iqbal, Chumki Choudhury, Thabet Alhousami, Sami Chogle, Alexa S. Acosta, Lana Fagman, Kelly Deabold, Marilia Takada, Bikash Sahay, Vikas Kumar, Manish V. Bais
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:International Journal of Oral Science
Online Access:https://doi.org/10.1038/s41368-025-00363-x
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