The association between oral microbiome and gastric precancerous lesions
ABSTRACT Gastric precancerous lesions are thought to be precursors in the occurrence and development of gastric cancer through Correa's cascade. Recent studies have investigated the association between the oral microbiome and gastric precancerous lesions. However, there has yet to be a comprehe...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2025-01-01
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| Series: | mSystems |
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| Online Access: | https://journals.asm.org/doi/10.1128/msystems.01322-24 |
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| author | Yifei Chen Lei Lei Mengying Xia Ran Cheng He Cai Tao Hu |
| author_facet | Yifei Chen Lei Lei Mengying Xia Ran Cheng He Cai Tao Hu |
| author_sort | Yifei Chen |
| collection | DOAJ |
| description | ABSTRACT Gastric precancerous lesions are thought to be precursors in the occurrence and development of gastric cancer through Correa's cascade. Recent studies have investigated the association between the oral microbiome and gastric precancerous lesions. However, there has yet to be a comprehensive synthesis review of the existing literature on the relationship between oral microbiome and gastric precancerous lesions. A systematic review was conducted to characterize the literature on the association between oral microbiome and gastric precancerous lesions. The studies show that oral microbiome is dynamic in individuals with gastric precancerous lesions. Oral-derived microorganisms were colonized in the gastric precancerous lesions. Interactions between oral and gastric microbiomes affect the response of the host immunity. The abnormal proliferation of oral-associated microorganisms may be linked to the reduction of gastric acid. The present review supports the potential association between oral microbiome and gastric precancerous lesions. However, the interactions are complex and multifaceted, which require further investigation. |
| format | Article |
| id | doaj-art-0f7818c5382d42729bbac07a343fee16 |
| institution | Kabale University |
| issn | 2379-5077 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mSystems |
| spelling | doaj-art-0f7818c5382d42729bbac07a343fee162025-01-21T14:00:28ZengAmerican Society for MicrobiologymSystems2379-50772025-01-0110110.1128/msystems.01322-24The association between oral microbiome and gastric precancerous lesionsYifei Chen0Lei Lei1Mengying Xia2Ran Cheng3He Cai4Tao Hu5State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaABSTRACT Gastric precancerous lesions are thought to be precursors in the occurrence and development of gastric cancer through Correa's cascade. Recent studies have investigated the association between the oral microbiome and gastric precancerous lesions. However, there has yet to be a comprehensive synthesis review of the existing literature on the relationship between oral microbiome and gastric precancerous lesions. A systematic review was conducted to characterize the literature on the association between oral microbiome and gastric precancerous lesions. The studies show that oral microbiome is dynamic in individuals with gastric precancerous lesions. Oral-derived microorganisms were colonized in the gastric precancerous lesions. Interactions between oral and gastric microbiomes affect the response of the host immunity. The abnormal proliferation of oral-associated microorganisms may be linked to the reduction of gastric acid. The present review supports the potential association between oral microbiome and gastric precancerous lesions. However, the interactions are complex and multifaceted, which require further investigation.https://journals.asm.org/doi/10.1128/msystems.01322-24oral microbiomegastric precancerous lesionsatrophic gastritisintestinal metaplasia |
| spellingShingle | Yifei Chen Lei Lei Mengying Xia Ran Cheng He Cai Tao Hu The association between oral microbiome and gastric precancerous lesions mSystems oral microbiome gastric precancerous lesions atrophic gastritis intestinal metaplasia |
| title | The association between oral microbiome and gastric precancerous lesions |
| title_full | The association between oral microbiome and gastric precancerous lesions |
| title_fullStr | The association between oral microbiome and gastric precancerous lesions |
| title_full_unstemmed | The association between oral microbiome and gastric precancerous lesions |
| title_short | The association between oral microbiome and gastric precancerous lesions |
| title_sort | association between oral microbiome and gastric precancerous lesions |
| topic | oral microbiome gastric precancerous lesions atrophic gastritis intestinal metaplasia |
| url | https://journals.asm.org/doi/10.1128/msystems.01322-24 |
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