The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke
Background/Aim. Relatively few studies have investigated the association of prestroke glycemic control and clinical outcome in acute ischemic stroke (IS) patients, regardless of presence of diabetes mellitus (DM). The aim of this study was to investigate the importance of prestroke glycemic control...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2014/694569 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555165363732480 |
|---|---|
| author | Clara Hjalmarsson Karin Manhem Lena Bokemark Björn Andersson |
| author_facet | Clara Hjalmarsson Karin Manhem Lena Bokemark Björn Andersson |
| author_sort | Clara Hjalmarsson |
| collection | DOAJ |
| description | Background/Aim. Relatively few studies have investigated the association of prestroke glycemic control and clinical outcome in acute ischemic stroke (IS) patients, regardless of presence of diabetes mellitus (DM). The aim of this study was to investigate the importance of prestroke glycemic control on survival, stroke severity, and functional outcome of patients with acute IS. Methods. We performed a retrospective survival analysis of 501 patients with IS admitted to Sahlgrenska University Hospital from February 15, 2005, through May 31, 2009. The outcomes of interest were acute and long-term survival; the stroke severity (NIHSS) and the functional outcome, mRS, at 12 months. Results. HbA1c was a good predictor of acute (HR 1.45; CI, 1.09 to 1.93, P=0.011) and long-term mortality (HR 1.29; CI 1.03 to 1.62; P=0.029). Furthermore, HbA1c >6% was significantly correlated with acute stroke severity (OR 1.29; CI 1.01 to 1.67; P=0.042) and predicted worse functional outcome at 12 months (OR 2.68; CI 1.14 to 6.03; P=0.024). Conclusions. Our study suggests that poor glycemic control (baseline HbA1c) prior to IS is an independent risk factor for poor survival and a marker for increased stroke severity and unfavorable long-term functional outcome. |
| format | Article |
| id | doaj-art-0f6f4d359cbb47ce8975690d85987ed8 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-0f6f4d359cbb47ce8975690d85987ed82025-02-03T05:49:27ZengWileyStroke Research and Treatment2090-81052042-00562014-01-01201410.1155/2014/694569694569The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic StrokeClara Hjalmarsson0Karin Manhem1Lena Bokemark2Björn Andersson3The Department of Cardiology, Sahlgrenska University Hospital, Blå Stråket 3, 1st Floor, 405 30 Göteborg, SwedenThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 5, 1st Floor, 405 30 Göteborg, SwedenThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 5, 1st Floor, 405 30 Göteborg, SwedenThe Stroke Unit, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 5, 1st Floor, 405 30 Göteborg, SwedenBackground/Aim. Relatively few studies have investigated the association of prestroke glycemic control and clinical outcome in acute ischemic stroke (IS) patients, regardless of presence of diabetes mellitus (DM). The aim of this study was to investigate the importance of prestroke glycemic control on survival, stroke severity, and functional outcome of patients with acute IS. Methods. We performed a retrospective survival analysis of 501 patients with IS admitted to Sahlgrenska University Hospital from February 15, 2005, through May 31, 2009. The outcomes of interest were acute and long-term survival; the stroke severity (NIHSS) and the functional outcome, mRS, at 12 months. Results. HbA1c was a good predictor of acute (HR 1.45; CI, 1.09 to 1.93, P=0.011) and long-term mortality (HR 1.29; CI 1.03 to 1.62; P=0.029). Furthermore, HbA1c >6% was significantly correlated with acute stroke severity (OR 1.29; CI 1.01 to 1.67; P=0.042) and predicted worse functional outcome at 12 months (OR 2.68; CI 1.14 to 6.03; P=0.024). Conclusions. Our study suggests that poor glycemic control (baseline HbA1c) prior to IS is an independent risk factor for poor survival and a marker for increased stroke severity and unfavorable long-term functional outcome.http://dx.doi.org/10.1155/2014/694569 |
| spellingShingle | Clara Hjalmarsson Karin Manhem Lena Bokemark Björn Andersson The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke Stroke Research and Treatment |
| title | The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke |
| title_full | The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke |
| title_fullStr | The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke |
| title_full_unstemmed | The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke |
| title_short | The Role of Prestroke Glycemic Control on Severity and Outcome of Acute Ischemic Stroke |
| title_sort | role of prestroke glycemic control on severity and outcome of acute ischemic stroke |
| url | http://dx.doi.org/10.1155/2014/694569 |
| work_keys_str_mv | AT clarahjalmarsson theroleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT karinmanhem theroleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT lenabokemark theroleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT bjornandersson theroleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT clarahjalmarsson roleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT karinmanhem roleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT lenabokemark roleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke AT bjornandersson roleofprestrokeglycemiccontrolonseverityandoutcomeofacuteischemicstroke |