Immune Thrombocytopenia in a Child with Neuroblastoma

Thrombocytopenia is a frequent finding in patients with solid tumors. It is usually caused by bone marrow infiltration or by myelosuppression due to anticancer therapy; however immune thrombocytopenia (ITP) associated with solid tumors is rare. Neuroblastoma is the most common extracranial solid tum...

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Main Authors: Hasan Tarkan Ikizoglu, Inci Ayan, Fatma Tokat, Tulay Tecimer, Gonca Topuzlu Tekant
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Case Reports in Pediatrics
Online Access:http://dx.doi.org/10.1155/2017/1329489
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author Hasan Tarkan Ikizoglu
Inci Ayan
Fatma Tokat
Tulay Tecimer
Gonca Topuzlu Tekant
author_facet Hasan Tarkan Ikizoglu
Inci Ayan
Fatma Tokat
Tulay Tecimer
Gonca Topuzlu Tekant
author_sort Hasan Tarkan Ikizoglu
collection DOAJ
description Thrombocytopenia is a frequent finding in patients with solid tumors. It is usually caused by bone marrow infiltration or by myelosuppression due to anticancer therapy; however immune thrombocytopenia (ITP) associated with solid tumors is rare. Neuroblastoma is the most common extracranial solid tumor in children. Here we report the case of a two-year-nine-month-old patient with adrenal neuroblastoma who presented with ITP. Paraneoplastic ITP was considered in the differential diagnosis. Bone marrow infiltration and other causes of thrombocytopenia were excluded and the patient was treated with intravenous immunoglobulin and tumor resection. Platelet count increased rapidly after surgery and complete remission of ITP was achieved.
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institution Kabale University
issn 2090-6803
2090-6811
language English
publishDate 2017-01-01
publisher Wiley
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series Case Reports in Pediatrics
spelling doaj-art-0f6cdbda4da7457db91d74c728f6e67e2025-02-03T05:59:16ZengWileyCase Reports in Pediatrics2090-68032090-68112017-01-01201710.1155/2017/13294891329489Immune Thrombocytopenia in a Child with NeuroblastomaHasan Tarkan Ikizoglu0Inci Ayan1Fatma Tokat2Tulay Tecimer3Gonca Topuzlu Tekant4Department of Pediatrics, Acibadem University Medical Faculty, Istanbul, TurkeyDepartment of Pediatrics, Acibadem Maslak Hospital, Istanbul, TurkeyDepartment of Pathology, Acibadem Maslak Hospital, Istanbul, TurkeyDepartment of Pathology, Acibadem Maslak Hospital, Istanbul, TurkeyDepartment of Pediatric Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, TurkeyThrombocytopenia is a frequent finding in patients with solid tumors. It is usually caused by bone marrow infiltration or by myelosuppression due to anticancer therapy; however immune thrombocytopenia (ITP) associated with solid tumors is rare. Neuroblastoma is the most common extracranial solid tumor in children. Here we report the case of a two-year-nine-month-old patient with adrenal neuroblastoma who presented with ITP. Paraneoplastic ITP was considered in the differential diagnosis. Bone marrow infiltration and other causes of thrombocytopenia were excluded and the patient was treated with intravenous immunoglobulin and tumor resection. Platelet count increased rapidly after surgery and complete remission of ITP was achieved.http://dx.doi.org/10.1155/2017/1329489
spellingShingle Hasan Tarkan Ikizoglu
Inci Ayan
Fatma Tokat
Tulay Tecimer
Gonca Topuzlu Tekant
Immune Thrombocytopenia in a Child with Neuroblastoma
Case Reports in Pediatrics
title Immune Thrombocytopenia in a Child with Neuroblastoma
title_full Immune Thrombocytopenia in a Child with Neuroblastoma
title_fullStr Immune Thrombocytopenia in a Child with Neuroblastoma
title_full_unstemmed Immune Thrombocytopenia in a Child with Neuroblastoma
title_short Immune Thrombocytopenia in a Child with Neuroblastoma
title_sort immune thrombocytopenia in a child with neuroblastoma
url http://dx.doi.org/10.1155/2017/1329489
work_keys_str_mv AT hasantarkanikizoglu immunethrombocytopeniainachildwithneuroblastoma
AT inciayan immunethrombocytopeniainachildwithneuroblastoma
AT fatmatokat immunethrombocytopeniainachildwithneuroblastoma
AT tulaytecimer immunethrombocytopeniainachildwithneuroblastoma
AT goncatopuzlutekant immunethrombocytopeniainachildwithneuroblastoma