The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.

The m6A demethylase FTO regulates TNF-α expression in human macrophages following Toxoplasma gondii infection.

Toxoplasma gondii (T. gondii) is an opportunistic parasite. After infection, macrophages finely regulate the immune response to restrict parasite proliferation. It is well-known that N6-methyladenosine (m6A) plays a critical role in fine-tuning gene expression. To investigate whether m6A modificatio...

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Bibliographic Details
Main Authors: Min Qin, Nan Gao, Jierui Sun, Shuqing Lin, Tingting Hu, Xinjian Liu, Rong Zhang, Yong Wang, Jingfan Qiu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0013289
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