The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation
Butyrate and butyrate-producing bacteria are important indicators of gut microbial metabolism in human health. Ten non-digestible carbohydrates (NDCs), including inulin, fructooligosaccharide (FOS), oats β-glucans (OGS), oats β-glucan oligosaccharides (OGOS), Astragalus polysaccharides (APS), Astrag...
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000903 |
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| author | Jingjing Xu Ruyue Wang Weibao Liu Zhongwei Yin Jianrong Wu Xun Yu Wen Wang Hongtao Zhang Zhitao Li Minjie Gao Li Zhu Xiaobei Zhan |
| author_facet | Jingjing Xu Ruyue Wang Weibao Liu Zhongwei Yin Jianrong Wu Xun Yu Wen Wang Hongtao Zhang Zhitao Li Minjie Gao Li Zhu Xiaobei Zhan |
| author_sort | Jingjing Xu |
| collection | DOAJ |
| description | Butyrate and butyrate-producing bacteria are important indicators of gut microbial metabolism in human health. Ten non-digestible carbohydrates (NDCs), including inulin, fructooligosaccharide (FOS), oats β-glucans (OGS), oats β-glucan oligosaccharides (OGOS), Astragalus polysaccharides (APS), Astragalus oligosaccharides (AOS), xanthan gum oligosaccharides (XGOS), gellan gum oligosaccharides (GGOS), curdlan oligosaccharides (COS), and pullulan oligosaccharides (POS) were used to investigate NDC specificity in modulating butyrate-producing bacteria and butyrate production in 48-h in vitro fermentation studies in combination with fecal inocula from 7 healthy donors and 11 patients with type 2 diabetes (T2D). We observed that the amount of these ten NDCs utilized depended on NDC structure and inter-individual gut microbial differences. XGOS and GGOS fermentations significantly increased butyrate-producing bacteria (especially f_Lachnospiraceae) and butyric acid production. Furthermore, XGOS and GGOS fermentations showed a better ability to consistently modulate gut microbiota composition and metabolic properties between individuals of healthy donors or T2D patients when compared to inulin, FOS, APS, AOS, OGS, OGOS, COS and POS fermentation. This research indicated that xanthan gum and gellan gum oligosaccharides have strong specificity to enhance butyrate-producing bacteria and butyrate production. |
| format | Article |
| id | doaj-art-0f51c26138a14b7087d9c6f157457f20 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-0f51c26138a14b7087d9c6f157457f202025-02-03T05:13:52ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112623442354The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentationJingjing Xu0Ruyue Wang1Weibao Liu2Zhongwei Yin3Jianrong Wu4Xun Yu5Wen Wang6Hongtao Zhang7Zhitao Li8Minjie Gao9Li Zhu10Xiaobei Zhan11Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaWuxi Second People's Hospital, Wuxi 214125, ChinaWuxi Second People's Hospital, Wuxi 214125, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, ChinaL & F Biotech. Ltd. 7144 Collister Dr. Burnaby BC V5A3P6, CanadaKey Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China; Corresponding author at: School of Biotechnology, Jiangnan University, Wuxi 214122, China.Butyrate and butyrate-producing bacteria are important indicators of gut microbial metabolism in human health. Ten non-digestible carbohydrates (NDCs), including inulin, fructooligosaccharide (FOS), oats β-glucans (OGS), oats β-glucan oligosaccharides (OGOS), Astragalus polysaccharides (APS), Astragalus oligosaccharides (AOS), xanthan gum oligosaccharides (XGOS), gellan gum oligosaccharides (GGOS), curdlan oligosaccharides (COS), and pullulan oligosaccharides (POS) were used to investigate NDC specificity in modulating butyrate-producing bacteria and butyrate production in 48-h in vitro fermentation studies in combination with fecal inocula from 7 healthy donors and 11 patients with type 2 diabetes (T2D). We observed that the amount of these ten NDCs utilized depended on NDC structure and inter-individual gut microbial differences. XGOS and GGOS fermentations significantly increased butyrate-producing bacteria (especially f_Lachnospiraceae) and butyric acid production. Furthermore, XGOS and GGOS fermentations showed a better ability to consistently modulate gut microbiota composition and metabolic properties between individuals of healthy donors or T2D patients when compared to inulin, FOS, APS, AOS, OGS, OGOS, COS and POS fermentation. This research indicated that xanthan gum and gellan gum oligosaccharides have strong specificity to enhance butyrate-producing bacteria and butyrate production.http://www.sciencedirect.com/science/article/pii/S2213453023000903Non-digestible carbohydratesGut microbiotaButyric acidButyrate-producing bacteria |
| spellingShingle | Jingjing Xu Ruyue Wang Weibao Liu Zhongwei Yin Jianrong Wu Xun Yu Wen Wang Hongtao Zhang Zhitao Li Minjie Gao Li Zhu Xiaobei Zhan The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation Food Science and Human Wellness Non-digestible carbohydrates Gut microbiota Butyric acid Butyrate-producing bacteria |
| title | The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation |
| title_full | The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation |
| title_fullStr | The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation |
| title_full_unstemmed | The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation |
| title_short | The specificity of ten non-digestible carbohydrates to enhance butyrate-producing bacteria and butyrate production in vitro fermentation |
| title_sort | specificity of ten non digestible carbohydrates to enhance butyrate producing bacteria and butyrate production in vitro fermentation |
| topic | Non-digestible carbohydrates Gut microbiota Butyric acid Butyrate-producing bacteria |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000903 |
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