CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions
A 95-year-old man came with violaceous nodular skin lesions of the left shin. The lesions were not painful or pruritic but progressed rapidly over the 3 months. Fever, night sweats, weight loss, and other systemic symptoms were absent. Shave biopsy of the lesion revealed the cells negative for CD20...
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| Language: | English |
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Knowledge E
2023-09-01
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| Series: | Sudan Journal of Medical Sciences |
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| Online Access: | https://knepublishing.com/index.php/SJMS/article/view/14083 |
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| author | Dalya M. M. Abdelmaged Carol A. Avila Abubaker A MohamedSharif Isra Bdraldein Salih Mohammed |
| author_facet | Dalya M. M. Abdelmaged Carol A. Avila Abubaker A MohamedSharif Isra Bdraldein Salih Mohammed |
| author_sort | Dalya M. M. Abdelmaged |
| collection | DOAJ |
| description |
A 95-year-old man came with violaceous nodular skin lesions of the left shin. The lesions were not painful or pruritic but progressed rapidly over the 3 months. Fever, night sweats, weight loss, and other systemic symptoms were absent. Shave biopsy of the lesion revealed the cells negative for CD20 but positive for BCL2, BCL6, FOX-P1, and CD10. PET/CT showed high uptake in the left leg and a sizeable hypermetabolic lymph node in the left pelvis. The patient was started on rituximab treatment as a single agent. This report highlights some of the diagnostic and treatment difficulties in CD20 negative lymphomas and the importance of a multidisciplinary approach in those cases.
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| format | Article |
| id | doaj-art-0f4e81236370460f9badcd56b532391e |
| institution | Kabale University |
| issn | 1858-5051 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj-art-0f4e81236370460f9badcd56b532391e2025-01-21T09:33:18ZengKnowledge ESudan Journal of Medical Sciences1858-50512023-09-0118310.18502/sjms.v18i3.14083CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin LesionsDalya M. M. Abdelmaged0Carol A. Avila1Abubaker A MohamedSharif2Isra Bdraldein Salih Mohammed3Faculty of Medicine, Al Neelain University, Khartoum, SudanUniversidad de Carabobo, Valencia, VenezuelaFaculty of Medicine, University of Khartoum, Khartoum, SudanFaculty of Medicine, University of Khartoum, Khartoum, Sudan A 95-year-old man came with violaceous nodular skin lesions of the left shin. The lesions were not painful or pruritic but progressed rapidly over the 3 months. Fever, night sweats, weight loss, and other systemic symptoms were absent. Shave biopsy of the lesion revealed the cells negative for CD20 but positive for BCL2, BCL6, FOX-P1, and CD10. PET/CT showed high uptake in the left leg and a sizeable hypermetabolic lymph node in the left pelvis. The patient was started on rituximab treatment as a single agent. This report highlights some of the diagnostic and treatment difficulties in CD20 negative lymphomas and the importance of a multidisciplinary approach in those cases. https://knepublishing.com/index.php/SJMS/article/view/14083diffuse large B-cell lymphoma, leg type (DLBCL-LT)primary cutaneous diffuse large B-cell lymphomaleg type (PCDLBCL-LT)positron emission tomography/computed tomography (PET/CT)cluster of differentiation (CD)B-cell lymphoma 2 (BCL2) |
| spellingShingle | Dalya M. M. Abdelmaged Carol A. Avila Abubaker A MohamedSharif Isra Bdraldein Salih Mohammed CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions Sudan Journal of Medical Sciences diffuse large B-cell lymphoma, leg type (DLBCL-LT) primary cutaneous diffuse large B-cell lymphoma leg type (PCDLBCL-LT) positron emission tomography/computed tomography (PET/CT) cluster of differentiation (CD) B-cell lymphoma 2 (BCL2) |
| title | CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions |
| title_full | CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions |
| title_fullStr | CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions |
| title_full_unstemmed | CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions |
| title_short | CD20 Negative Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type with Rapidly Progressing Skin Lesions |
| title_sort | cd20 negative primary cutaneous diffuse large b cell lymphoma leg type with rapidly progressing skin lesions |
| topic | diffuse large B-cell lymphoma, leg type (DLBCL-LT) primary cutaneous diffuse large B-cell lymphoma leg type (PCDLBCL-LT) positron emission tomography/computed tomography (PET/CT) cluster of differentiation (CD) B-cell lymphoma 2 (BCL2) |
| url | https://knepublishing.com/index.php/SJMS/article/view/14083 |
| work_keys_str_mv | AT dalyammabdelmaged cd20negativeprimarycutaneousdiffuselargebcelllymphomalegtypewithrapidlyprogressingskinlesions AT carolaavila cd20negativeprimarycutaneousdiffuselargebcelllymphomalegtypewithrapidlyprogressingskinlesions AT abubakeramohamedsharif cd20negativeprimarycutaneousdiffuselargebcelllymphomalegtypewithrapidlyprogressingskinlesions AT israbdraldeinsalihmohammed cd20negativeprimarycutaneousdiffuselargebcelllymphomalegtypewithrapidlyprogressingskinlesions |