Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma
Hemangioma is the most common vascular tumor of infancy; presentation is often as cutaneous infantile hemangioma (IH). Cutaneous hemangioma is a clinical diagnosis. Most IHs follow a benign course, with complete involution without treatment in the majority of cases. Visceral hemangioma often involve...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2016/9803975 |
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| author | Siu Ying Angel Nip Kam Lun Hon Wing Kwan Alex Leung Alexander K. C. Leung Paul C. L. Choi |
| author_facet | Siu Ying Angel Nip Kam Lun Hon Wing Kwan Alex Leung Alexander K. C. Leung Paul C. L. Choi |
| author_sort | Siu Ying Angel Nip |
| collection | DOAJ |
| description | Hemangioma is the most common vascular tumor of infancy; presentation is often as cutaneous infantile hemangioma (IH). Cutaneous hemangioma is a clinical diagnosis. Most IHs follow a benign course, with complete involution without treatment in the majority of cases. Visceral hemangioma often involves the liver and manifests as a life-threatening disorder. Hepatic hemangiomas may be associated with high output cardiac failure, coagulopathy, and hepatomegaly which generally develop between 1 and 16 weeks of age. Mortality has been reportedly high without treatment. We report a rare case of a male infant with neonatal hemangiomatosis with diffuse peritoneal involvement, which mimicked a malignant-looking tumor on imaging, and discuss therapeutic options and efficacy. Propranolol is efficacious for IH but generally not useful for other forms of vascular hemangiomas, tumors, and malformations. In our case of neonatal peritoneal hemangiomatosis, propranolol appears to have halted the growth and possibly expedite the involution of the hemangiomatosis without other treatments. |
| format | Article |
| id | doaj-art-0f4882b4cdb44900925a19de67cb2990 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-0f4882b4cdb44900925a19de67cb29902025-02-03T01:28:49ZengWileyCase Reports in Pediatrics2090-68032090-68112016-01-01201610.1155/2016/98039759803975Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile HemangiomaSiu Ying Angel Nip0Kam Lun Hon1Wing Kwan Alex Leung2Alexander K. C. Leung3Paul C. L. Choi4Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong KongDepartment of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong KongDepartment of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong KongDepartment of Paediatrics, University of Calgary, 200-233 16th Avenue NW, Calgary, AB, T2M 0H5, CanadaDepartment of Anatomical & Cellular Pathology, Prince of Wales Hospital, Shatin, Hong KongHemangioma is the most common vascular tumor of infancy; presentation is often as cutaneous infantile hemangioma (IH). Cutaneous hemangioma is a clinical diagnosis. Most IHs follow a benign course, with complete involution without treatment in the majority of cases. Visceral hemangioma often involves the liver and manifests as a life-threatening disorder. Hepatic hemangiomas may be associated with high output cardiac failure, coagulopathy, and hepatomegaly which generally develop between 1 and 16 weeks of age. Mortality has been reportedly high without treatment. We report a rare case of a male infant with neonatal hemangiomatosis with diffuse peritoneal involvement, which mimicked a malignant-looking tumor on imaging, and discuss therapeutic options and efficacy. Propranolol is efficacious for IH but generally not useful for other forms of vascular hemangiomas, tumors, and malformations. In our case of neonatal peritoneal hemangiomatosis, propranolol appears to have halted the growth and possibly expedite the involution of the hemangiomatosis without other treatments.http://dx.doi.org/10.1155/2016/9803975 |
| spellingShingle | Siu Ying Angel Nip Kam Lun Hon Wing Kwan Alex Leung Alexander K. C. Leung Paul C. L. Choi Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma Case Reports in Pediatrics |
| title | Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma |
| title_full | Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma |
| title_fullStr | Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma |
| title_full_unstemmed | Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma |
| title_short | Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma |
| title_sort | neonatal abdominal hemangiomatosis propranolol beyond infantile hemangioma |
| url | http://dx.doi.org/10.1155/2016/9803975 |
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