PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion

PD-1 downregulation enhances CAR-T cell antitumor efficiency by preserving a cell memory phenotype and reducing exhaustion

Background Despite the encouraging outcome of chimeric antigen receptor T cell (CAR-T) targeting B cell maturation antigen (BCMA) in managing relapsed or refractory multiple myeloma (RRMM) patients, the therapeutic side effects and dysfunctions of CAR-T cells have limited the efficacy and clinical a...

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Main Authors: Lei Yu, Yan Wang, Jin Wang, Zhiqiang Liu, Feng Liu, Han Zhao, Yi Tao, Jian-Qing Mi, Nan Xu, Wanyan Ouyang, Shi-Wei Jin, Wei-Yang Liu, Liuqingqing Zhang, Liqing Kang, Yuanfang Liu
Format: Article
Language:English
Published: BMJ Publishing Group 2024-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/4/e008429.full
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