Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy
Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing atten...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177924002363 |
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| author | Ling Ding Xiaoshan Wang Qing Wu Xia Wang Qigang Wang |
| author_facet | Ling Ding Xiaoshan Wang Qing Wu Xia Wang Qigang Wang |
| author_sort | Ling Ding |
| collection | DOAJ |
| description | Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. Benefiting from photothermal-induced hyperthermia upon near-infrared (NIR) laser exposure, the exogenous ROS (including H2O2) were boosted by the AuNR nanogel owing to the intercellular stress response. This ultimately promoted the efficient enzyme-catalyzed reaction of loaded CPO combined with the rich endogenous H2O2 in tumor cells to significantly elevate intracellular ROS levels above the threshold for improved therapeutic outcomes. Both in vitro and in vivo studies have verified the cascade-amplifying ROS-mediated antitumor effects, providing feasible multimodal synergistic tactics for tumor treatment. |
| format | Article |
| id | doaj-art-0f41036cc6f74a72afc8ae9c6e373272 |
| institution | Kabale University |
| issn | 2095-1779 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj-art-0f41036cc6f74a72afc8ae9c6e3732722025-01-30T05:13:59ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412101139Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapyLing Ding0Xiaoshan Wang1Qing Wu2Xia Wang3Qigang Wang4School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, ChinaSchool of Chemical Science and Engineering, Tongji University, Shanghai, 200092, ChinaShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; Corresponding author.School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China; Corresponding author.School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China; Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China; Corresponding author. School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, China.Reactive oxygen species (ROS)-mediated anticancer modalities, which disturb the redox balance of cancer cells through multi-pathway simulations, hold great promise for effective cancer management. Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. Benefiting from photothermal-induced hyperthermia upon near-infrared (NIR) laser exposure, the exogenous ROS (including H2O2) were boosted by the AuNR nanogel owing to the intercellular stress response. This ultimately promoted the efficient enzyme-catalyzed reaction of loaded CPO combined with the rich endogenous H2O2 in tumor cells to significantly elevate intracellular ROS levels above the threshold for improved therapeutic outcomes. Both in vitro and in vivo studies have verified the cascade-amplifying ROS-mediated antitumor effects, providing feasible multimodal synergistic tactics for tumor treatment.http://www.sciencedirect.com/science/article/pii/S2095177924002363NanogelsPhotothermal-enzymatic synergistic therapyROS-Based nanodynamic therapies |
| spellingShingle | Ling Ding Xiaoshan Wang Qing Wu Xia Wang Qigang Wang Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy Journal of Pharmaceutical Analysis Nanogels Photothermal-enzymatic synergistic therapy ROS-Based nanodynamic therapies |
| title | Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy |
| title_full | Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy |
| title_fullStr | Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy |
| title_full_unstemmed | Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy |
| title_short | Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy |
| title_sort | gold nanorod based engineered nanogels for cascade amplifying photothermo enzymatic synergistic therapy |
| topic | Nanogels Photothermal-enzymatic synergistic therapy ROS-Based nanodynamic therapies |
| url | http://www.sciencedirect.com/science/article/pii/S2095177924002363 |
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