Bidirectional relationship between sleep and depression
Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram delta power during non-REM sleep. Insufficient sleep can be stressful, and the accumulation of stress leads to the deterio...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010223000871 |
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| author | Shinnosuke Yasugaki Hibiki Okamura Ami Kaneko Yu Hayashi |
| author_facet | Shinnosuke Yasugaki Hibiki Okamura Ami Kaneko Yu Hayashi |
| author_sort | Shinnosuke Yasugaki |
| collection | DOAJ |
| description | Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram delta power during non-REM sleep. Insufficient sleep can be stressful, and the accumulation of stress leads to the deterioration of mental health and contributes to the development of psychiatric disorders. Thus, it is likely that depression and sleep are bidirectionally related, i.e. development of depression contributes to sleep disturbances and vice versa. However, the relation between depression and sleep seems complicated. For example, acute sleep deprivation can paradoxically improve depressive symptoms. Thus, it is difficult to conclude whether sleep has beneficial or harmful effects in patients with depression. How antidepressants affect sleep in patients with depression might provide clues to understanding the effects of sleep, but caution is required considering that antidepressants have diverse effects other than sleep. Recent animal studies support the bidirectional relation between depression and sleep, and animal models of depression are expected to be beneficial for the identification of neuronal circuits that connect stress, sleep, and depression. This review provides a comprehensive overview regarding the current knowledge of the relationship between depression and sleep. |
| format | Article |
| id | doaj-art-0f3db24aa54b4339a526a7f491672926 |
| institution | Kabale University |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-0f3db24aa54b4339a526a7f4916729262025-02-06T05:11:00ZengElsevierNeuroscience Research0168-01022025-02-012115764Bidirectional relationship between sleep and depressionShinnosuke Yasugaki0Hibiki Okamura1Ami Kaneko2Yu Hayashi3International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; Japan Society for the Promotion of Science (JSPS), Tokyo 102-0083, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Japan Society for the Promotion of Science (JSPS), Tokyo 102-0083, Japan; Program in Humanics, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Ibaraki 305-8575, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Program in Humanics, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Ibaraki 305-8575, JapanInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan; Corresponding author at: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.Patients with depression almost inevitably exhibit abnormalities in sleep, such as shortened latency to enter rapid eye movement (REM) sleep and decrease in electroencephalogram delta power during non-REM sleep. Insufficient sleep can be stressful, and the accumulation of stress leads to the deterioration of mental health and contributes to the development of psychiatric disorders. Thus, it is likely that depression and sleep are bidirectionally related, i.e. development of depression contributes to sleep disturbances and vice versa. However, the relation between depression and sleep seems complicated. For example, acute sleep deprivation can paradoxically improve depressive symptoms. Thus, it is difficult to conclude whether sleep has beneficial or harmful effects in patients with depression. How antidepressants affect sleep in patients with depression might provide clues to understanding the effects of sleep, but caution is required considering that antidepressants have diverse effects other than sleep. Recent animal studies support the bidirectional relation between depression and sleep, and animal models of depression are expected to be beneficial for the identification of neuronal circuits that connect stress, sleep, and depression. This review provides a comprehensive overview regarding the current knowledge of the relationship between depression and sleep.http://www.sciencedirect.com/science/article/pii/S0168010223000871REM sleepNREM sleepStressDepressionAntidepressants |
| spellingShingle | Shinnosuke Yasugaki Hibiki Okamura Ami Kaneko Yu Hayashi Bidirectional relationship between sleep and depression Neuroscience Research REM sleep NREM sleep Stress Depression Antidepressants |
| title | Bidirectional relationship between sleep and depression |
| title_full | Bidirectional relationship between sleep and depression |
| title_fullStr | Bidirectional relationship between sleep and depression |
| title_full_unstemmed | Bidirectional relationship between sleep and depression |
| title_short | Bidirectional relationship between sleep and depression |
| title_sort | bidirectional relationship between sleep and depression |
| topic | REM sleep NREM sleep Stress Depression Antidepressants |
| url | http://www.sciencedirect.com/science/article/pii/S0168010223000871 |
| work_keys_str_mv | AT shinnosukeyasugaki bidirectionalrelationshipbetweensleepanddepression AT hibikiokamura bidirectionalrelationshipbetweensleepanddepression AT amikaneko bidirectionalrelationshipbetweensleepanddepression AT yuhayashi bidirectionalrelationshipbetweensleepanddepression |