TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State
Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset. In the last ten years, a causal role in carci...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/161837 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554543949283328 |
|---|---|
| author | Simone Cardaci Maria Rosa Ciriolo |
| author_facet | Simone Cardaci Maria Rosa Ciriolo |
| author_sort | Simone Cardaci |
| collection | DOAJ |
| description | Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset. In the last ten years, a causal role in carcinogenesis has been documented for inherited and acquired alterations in three TCA cycle enzymes, succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH), pointing towards metabolic alterations as the underlying hallmark of cancer. This paper summarizes the neoplastic alterations of the TCA cycle enzymes focusing on the generation of pseudohypoxic phenotype and the alteration of epigenetic homeostasis as the main tumor-promoting effects of the TCA cycle affecting defects. Moreover, we debate on the ability of these mutations to affect cellular redox state and to promote carcinogenesis by impacting on redox biology. |
| format | Article |
| id | doaj-art-0f352b287fe64c21a48bdf1c954374f9 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-0f352b287fe64c21a48bdf1c954374f92025-02-03T05:51:04ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/161837161837TCA Cycle Defects and Cancer: When Metabolism Tunes Redox StateSimone Cardaci0Maria Rosa Ciriolo1Department of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, ItalyDepartment of Biology, University of Rome “Tor Vergata”, Via della Ricerca Scientifica, 00133 Rome, ItalyInborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset. In the last ten years, a causal role in carcinogenesis has been documented for inherited and acquired alterations in three TCA cycle enzymes, succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH), pointing towards metabolic alterations as the underlying hallmark of cancer. This paper summarizes the neoplastic alterations of the TCA cycle enzymes focusing on the generation of pseudohypoxic phenotype and the alteration of epigenetic homeostasis as the main tumor-promoting effects of the TCA cycle affecting defects. Moreover, we debate on the ability of these mutations to affect cellular redox state and to promote carcinogenesis by impacting on redox biology.http://dx.doi.org/10.1155/2012/161837 |
| spellingShingle | Simone Cardaci Maria Rosa Ciriolo TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State International Journal of Cell Biology |
| title | TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State |
| title_full | TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State |
| title_fullStr | TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State |
| title_full_unstemmed | TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State |
| title_short | TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State |
| title_sort | tca cycle defects and cancer when metabolism tunes redox state |
| url | http://dx.doi.org/10.1155/2012/161837 |
| work_keys_str_mv | AT simonecardaci tcacycledefectsandcancerwhenmetabolismtunesredoxstate AT mariarosaciriolo tcacycledefectsandcancerwhenmetabolismtunesredoxstate |