Robust DNA repair in PAXX‐deficient mammalian cells

Robust DNA repair in PAXX‐deficient mammalian cells

To ensure genome stability, mammalian cells employ several DNA repair pathways. Nonhomologous DNA end joining (NHEJ) is the DNA repair process that fixes double‐strand breaks throughout the cell cycle. NHEJ is involved in the development of B and T lymphocytes through its function in V(D)J recombina...

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Main Authors: Alisa Dewan, Mengtan Xing, Marie Benner Lundbæk, Raquel Gago‐Fuentes, Carole Beck, Per Arne Aas, Nina‐Beate Liabakk, Siri Sæterstad, Khac Thanh Phong Chau, Bodil Merete Kavli, Valentyn Oksenych
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:FEBS Open Bio
Subjects:
CH12F3
class switch recombination
etoposide
HAP1
IgA
zeocin
Online Access:https://doi.org/10.1002/2211-5463.12380
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https://doi.org/10.1002/2211-5463.12380

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