The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19
Background. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/2395212 |
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| author | Ceyda Dincer Yazan Can Ilgin Onur Elbasan Tugce Apaydin Saida Dashdamirova Tayfun Yigit Uluhan Sili Aysegul Karahasan Yagci Onder Sirikci Goncagul Haklar Hulya Gozu |
| author_facet | Ceyda Dincer Yazan Can Ilgin Onur Elbasan Tugce Apaydin Saida Dashdamirova Tayfun Yigit Uluhan Sili Aysegul Karahasan Yagci Onder Sirikci Goncagul Haklar Hulya Gozu |
| author_sort | Ceyda Dincer Yazan |
| collection | DOAJ |
| description | Background. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. Results. 34.1% of the patients were euthyroid. Length of hospitalization (p<0.001), rate of oxygen demand (p<0.001), and intensive care unit (ICU) admission (p=0.022) were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease. |
| format | Article |
| id | doaj-art-0ef47bc693304fbbafe25bed754d01d8 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0ef47bc693304fbbafe25bed754d01d82025-02-03T01:27:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452021-01-01202110.1155/2021/23952122395212The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19Ceyda Dincer Yazan0Can Ilgin1Onur Elbasan2Tugce Apaydin3Saida Dashdamirova4Tayfun Yigit5Uluhan Sili6Aysegul Karahasan Yagci7Onder Sirikci8Goncagul Haklar9Hulya Gozu10Marmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, TurkeyMarmara University School of Medicine, Department of Public Health, Istanbul, TurkeyMarmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, TurkeyMarmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, TurkeyMarmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, TurkeyMarmara University School of Medicine, Department of Biochemistry, Istanbul, TurkeyMarmara University School of Medicine, Department of Infectious Diseases and Clinical Microbiology, Istanbul, TurkeyMarmara University School of Medicine, Department of Microbiology, Istanbul, TurkeyMarmara University School of Medicine, Department of Biochemistry, Istanbul, TurkeyMarmara University School of Medicine, Department of Biochemistry, Istanbul, TurkeyMarmara University School of Medicine, Department of Endocrinology and Metabolism, Istanbul, TurkeyBackground. COVID-19 infection may have multiorgan effects in addition to effects on the lungs and immune system. Recently, studies have found thyroid function abnormalities in COVID-19 cases which were interpreted as euthyroid sick syndrome (ESS) or destructive thyroiditis. Therefore, in this study, we aimed to evaluate the thyroid function status and thyroid autoimmunity in COVID-19 patients. Material and Method. 205 patients were included. The medical history and laboratory parameters at admission were collected from medical records. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and thyroglobulin antibody were measured, and patients were classified according to thyroid function status. Results. 34.1% of the patients were euthyroid. Length of hospitalization (p<0.001), rate of oxygen demand (p<0.001), and intensive care unit (ICU) admission (p=0.022) were lower, and none of the euthyroid patients died. 108 (52.6%) patients were classified to have ESS, 57 were classified as mild, and 51 were moderate. The inflammatory parameters were higher in patients with moderate ESS. In cluster analysis, a high-risk group with a lower median FT3 value (median = 2.34 ng/L; IQR = 0.86), a higher median FT4 value (median = 1.04 ng/dL; IQR = 0.33), and a lower median TSH value (median = 0.62 mIU/L; IQR = 0.59) included 8 of 9 died patients and 25 of the 31 patients that were admitted to ICU. Discussion. Length of hospitalization, oxygen demand, ICU admission, and mortality were lower in euthyroid patients. Moreover, none of the euthyroid patients died. In conclusion, evaluation of thyroid function tests during COVID-19 infection may give information about the prognosis of disease.http://dx.doi.org/10.1155/2021/2395212 |
| spellingShingle | Ceyda Dincer Yazan Can Ilgin Onur Elbasan Tugce Apaydin Saida Dashdamirova Tayfun Yigit Uluhan Sili Aysegul Karahasan Yagci Onder Sirikci Goncagul Haklar Hulya Gozu The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 International Journal of Endocrinology |
| title | The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 |
| title_full | The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 |
| title_fullStr | The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 |
| title_full_unstemmed | The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 |
| title_short | The Association of Thyroid Hormone Changes with Inflammatory Status and Prognosis in COVID-19 |
| title_sort | association of thyroid hormone changes with inflammatory status and prognosis in covid 19 |
| url | http://dx.doi.org/10.1155/2021/2395212 |
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