The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen
The objective was to compare the efficacy and safety of naproxen (NXN) to acetylsalicylic acid (ASA) in the treatment of acute rheumatic fever (ARF). The data of 338 children were retrospectively analyzed. The patients were grouped according to joint and valve involvement and also drug chosen...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2016-10-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/1146 |
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| author | İbrahim İlker Çetin Murat Sürücü Mehmet Emre Arı Ayşe Esin Kibar Emine Azak Sancar Eminoğlu Berna Şaylan Çevik Abdullah Kocabaş Filiz Ekici Ali Orgun |
| author_facet | İbrahim İlker Çetin Murat Sürücü Mehmet Emre Arı Ayşe Esin Kibar Emine Azak Sancar Eminoğlu Berna Şaylan Çevik Abdullah Kocabaş Filiz Ekici Ali Orgun |
| author_sort | İbrahim İlker Çetin |
| collection | DOAJ |
| description |
The objective was to compare the efficacy and safety of naproxen (NXN) to acetylsalicylic acid (ASA) in the treatment of acute rheumatic fever (ARF). The data of 338 children were retrospectively analyzed. The patients were grouped according to joint and valve involvement and also drug chosen [methyl prednisolone (mPSL), ASA or NXN]. The treatment results and adverse events in each group were compared. The mean age was 10.3 years and the median follow-up was 62 months. Median time for normalization of acute phase reactants was 1 week in patients given steroids and 2 weeks in patients given ASA or NXN. ASA was replaced with NXN in 18 patients (10.2%) due to hepatic toxicity. The rate of rebound, recurrence and the prevalence of rheumatic valve disease were not different in patients given NXN, ASA or mPSL. In conclusion, NXN is a safe and effective alternative to ASA in the treatment of ARF in children.
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| format | Article |
| id | doaj-art-0ee467a5bdcc42618ffa04e952fd8d72 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-0ee467a5bdcc42618ffa04e952fd8d722025-08-20T03:01:11ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212016-10-0158510.24953/turkjped.2016.05.003The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxenİbrahim İlker Çetin0Murat Sürücü1Mehmet Emre Arı2Ayşe Esin Kibar3Emine Azak4Sancar Eminoğlu5Berna Şaylan Çevik6Abdullah Kocabaş7Filiz Ekici8Ali Orgun9Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey.Ankara Children's Hematology Oncology Training and Research Hospital, Pediatric Cardiology Clinic, Ankara, Turkey. The objective was to compare the efficacy and safety of naproxen (NXN) to acetylsalicylic acid (ASA) in the treatment of acute rheumatic fever (ARF). The data of 338 children were retrospectively analyzed. The patients were grouped according to joint and valve involvement and also drug chosen [methyl prednisolone (mPSL), ASA or NXN]. The treatment results and adverse events in each group were compared. The mean age was 10.3 years and the median follow-up was 62 months. Median time for normalization of acute phase reactants was 1 week in patients given steroids and 2 weeks in patients given ASA or NXN. ASA was replaced with NXN in 18 patients (10.2%) due to hepatic toxicity. The rate of rebound, recurrence and the prevalence of rheumatic valve disease were not different in patients given NXN, ASA or mPSL. In conclusion, NXN is a safe and effective alternative to ASA in the treatment of ARF in children. https://turkjpediatr.org/article/view/1146acetylsalicylic acidacute rheumatic feveradverse eventsefficacynaproxen |
| spellingShingle | İbrahim İlker Çetin Murat Sürücü Mehmet Emre Arı Ayşe Esin Kibar Emine Azak Sancar Eminoğlu Berna Şaylan Çevik Abdullah Kocabaş Filiz Ekici Ali Orgun The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen The Turkish Journal of Pediatrics acetylsalicylic acid acute rheumatic fever adverse events efficacy naproxen |
| title | The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen |
| title_full | The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen |
| title_fullStr | The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen |
| title_full_unstemmed | The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen |
| title_short | The efficacy and safety of naproxen in acute rheumatic fever: The comparative results of 11-year experience with acetylsalicylic acid and naproxen |
| title_sort | efficacy and safety of naproxen in acute rheumatic fever the comparative results of 11 year experience with acetylsalicylic acid and naproxen |
| topic | acetylsalicylic acid acute rheumatic fever adverse events efficacy naproxen |
| url | https://turkjpediatr.org/article/view/1146 |
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