TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27

TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27

Abstract Our previous studies demonstrated that FOSL1 promotes glioblastoma (GBM) progression and stemness through pathways such as STAT3 and NF-κB signaling. Recently, we identified that FOSL1 physically interacts with the nuclear E3 ligase TRIM21. This study investigates the role of TRIM21 in GBM,...

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Bibliographic Details
Main Authors: Vanajothi Ramar, Rajveer Singh Sidhu, Osei Pako, Cheyenne R. Cisse, Alyssa A. Guo, Jason Li, Kelcey Stapleton, Shanchun Guo, Guangdi Wang, Mingli Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Glioblastoma
TRIM21
FOSL1
p27
Ubiquitination
Online Access:https://doi.org/10.1186/s12964-025-02325-6
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