Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk
Epidemiological studies have suggested that interleukin-17 (IL-17) polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs) with 95% confidence intervals (CIs) were...
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/128490 |
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| _version_ | 1832563267792273408 |
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| author | Yu-Ming Niu Hua Yuan Yu Zhou |
| author_facet | Yu-Ming Niu Hua Yuan Yu Zhou |
| author_sort | Yu-Ming Niu |
| collection | DOAJ |
| description | Epidemiological studies have suggested that interleukin-17 (IL-17) polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association of the IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms with cancer risk. Publication bias and sensitivity analyses were performed to ensure the statistical power. Overall, 10 relevant case-control studies involving 4,516 cases and 5,645 controls were included. The pooled ORs with 95% CIs indicated that the IL-17A rs2275913G>A polymorphism was significantly associated with increased cancer risk (for A versus G: OR = 1.28, 95% CI: 1.16–1.41, P<0.001, I2=61.1%; for GA versus GG: OR = 1.12, 95% CI: 1.02–1.23, P = 0.015, I2=27.8%; for AA versus GG: OR = 1.71, 95% CI: 1.38–2.41, P<0.001, I2=69.6%; for GA + AA versus GG: OR = 1.23, 95% CI: 1.13–1.34, P<0.001, I2=6.4%; for AA versus GG + GA: OR = 1.62, 95% CI: 1.27–2.07, P<0.001, I2=81.4%). Succeeding analysis of HWE and stratified analysis of gastric cancer and the Asian (and Chinese) population revealed similar results. The IL-17F rs763780T>C polymorphism was also significantly associated with gastric cancer development. Overall, the present meta-analysis suggests that IL-17 polymorphisms increase the risk of developing cancer, particularly gastric cancer, in the Asian (and Chinese) population. |
| format | Article |
| id | doaj-art-0ebdbe62ecea45bea6305594a5bb1446 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0ebdbe62ecea45bea6305594a5bb14462025-02-03T01:20:33ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/128490128490Interleukin-17 Gene Polymorphisms Contribute to Cancer RiskYu-Ming Niu0Hua Yuan1Yu Zhou2Department of Stomatology and Evidence-Based Medicine Center, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan 442000, ChinaInstitute of Stomatology, Nanjing Medical University, No. 140 Hanzhong Road, Nanjing 210029, ChinaDepartment of Maxillofacial Surgery, Provincial Hospital Affiliated to Anhui Medical University, Hefei 232001, ChinaEpidemiological studies have suggested that interleukin-17 (IL-17) polymorphisms are associated with cancer risk. However, the results of these studies are inconsistent. Therefore, we performed a meta-analysis to obtain a precise conclusion. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association of the IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms with cancer risk. Publication bias and sensitivity analyses were performed to ensure the statistical power. Overall, 10 relevant case-control studies involving 4,516 cases and 5,645 controls were included. The pooled ORs with 95% CIs indicated that the IL-17A rs2275913G>A polymorphism was significantly associated with increased cancer risk (for A versus G: OR = 1.28, 95% CI: 1.16–1.41, P<0.001, I2=61.1%; for GA versus GG: OR = 1.12, 95% CI: 1.02–1.23, P = 0.015, I2=27.8%; for AA versus GG: OR = 1.71, 95% CI: 1.38–2.41, P<0.001, I2=69.6%; for GA + AA versus GG: OR = 1.23, 95% CI: 1.13–1.34, P<0.001, I2=6.4%; for AA versus GG + GA: OR = 1.62, 95% CI: 1.27–2.07, P<0.001, I2=81.4%). Succeeding analysis of HWE and stratified analysis of gastric cancer and the Asian (and Chinese) population revealed similar results. The IL-17F rs763780T>C polymorphism was also significantly associated with gastric cancer development. Overall, the present meta-analysis suggests that IL-17 polymorphisms increase the risk of developing cancer, particularly gastric cancer, in the Asian (and Chinese) population.http://dx.doi.org/10.1155/2014/128490 |
| spellingShingle | Yu-Ming Niu Hua Yuan Yu Zhou Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk Mediators of Inflammation |
| title | Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk |
| title_full | Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk |
| title_fullStr | Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk |
| title_full_unstemmed | Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk |
| title_short | Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk |
| title_sort | interleukin 17 gene polymorphisms contribute to cancer risk |
| url | http://dx.doi.org/10.1155/2014/128490 |
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