Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines
Anti-tubercular-glycolipid-IgG (TBGL-IgG) and -IgA (TBGL-IgA) antibodies, and the QuantiFERON-TB Gold test (QFT) were compared in healthcare workers (HCWs, n=31) and asymptomatic human immunodeficiency virus-carriers (HIV-AC, n=56) in Manila. In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/610707 |
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| author | Umme Ruman Siddiqi Prisca Susan A. Leano Haorile Chagan-Yasutan Beata Shiratori Hiroki Saitoh Yugo Ashino Yasuhiko Suzuki Toshio Hattori Elizabeth Freda O. Telan |
| author_facet | Umme Ruman Siddiqi Prisca Susan A. Leano Haorile Chagan-Yasutan Beata Shiratori Hiroki Saitoh Yugo Ashino Yasuhiko Suzuki Toshio Hattori Elizabeth Freda O. Telan |
| author_sort | Umme Ruman Siddiqi |
| collection | DOAJ |
| description | Anti-tubercular-glycolipid-IgG (TBGL-IgG) and -IgA (TBGL-IgA) antibodies, and the QuantiFERON-TB Gold test (QFT) were compared in healthcare workers (HCWs, n=31) and asymptomatic human immunodeficiency virus-carriers (HIV-AC, n=56) in Manila. In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG, and -IgA, respectively. The TBGL-IgG positivity was significantly higher (P=0.02) in QFT-positive than QFT-negative HCWs. Both TBGL-IgG- and -IgA-positive cases were only found in QFT-positive HCWs (27%). The plasma IFN-γ levels positively correlated with TBGL-IgA titers (r=0.74, P=0.005), but not TBGL-IgG titers in this group, indicating that mucosal immunity is involved in LTBI in immunocompetent individuals. The QFT positivity in HIV-AC was 31% in those with CD4+ cell counts >350/μL and 12.5% in low CD4 group (<350/μL). 59 % and 29% were positive for TBGL-IgG and -IgA, respectively, in HIV-AC, but no association was found between QFT and TBGL assays. TBGL-IgG-positive rates in QFT-positive and QFT-negative HIV-AC were 61% and 58%, and those of TBGL-IgA were 23% and 30%, respectively. The titers of TBGL-IgA were associated with serum IgA (P=0.02) in HIV-AC.
Elevations of TBGL-IgG and -IgA were related to latent tuberculosis infection in HCWs, but careful interpretation is necessary in HIV-AC. |
| format | Article |
| id | doaj-art-0ebb7788ed154c0096affc86e5d622da |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0ebb7788ed154c0096affc86e5d622da2025-02-03T01:21:14ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/610707610707Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the PhilippinesUmme Ruman Siddiqi0Prisca Susan A. Leano1Haorile Chagan-Yasutan2Beata Shiratori3Hiroki Saitoh4Yugo Ashino5Yasuhiko Suzuki6Toshio Hattori7Elizabeth Freda O. Telan8Division of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JapanSTD AIDS Cooperative Central Laboratory, San Lazaro Hospital, Manila, PhilippinesDivision of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JapanDivision of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JapanDivision of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JapanDivision of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JapanDepartment of Global Epidemiology, Research Centre for Zoonosis Control, Hokkaido University, Sapporo, JapanDivision of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, JapanSTD AIDS Cooperative Central Laboratory, San Lazaro Hospital, Manila, PhilippinesAnti-tubercular-glycolipid-IgG (TBGL-IgG) and -IgA (TBGL-IgA) antibodies, and the QuantiFERON-TB Gold test (QFT) were compared in healthcare workers (HCWs, n=31) and asymptomatic human immunodeficiency virus-carriers (HIV-AC, n=56) in Manila. In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG, and -IgA, respectively. The TBGL-IgG positivity was significantly higher (P=0.02) in QFT-positive than QFT-negative HCWs. Both TBGL-IgG- and -IgA-positive cases were only found in QFT-positive HCWs (27%). The plasma IFN-γ levels positively correlated with TBGL-IgA titers (r=0.74, P=0.005), but not TBGL-IgG titers in this group, indicating that mucosal immunity is involved in LTBI in immunocompetent individuals. The QFT positivity in HIV-AC was 31% in those with CD4+ cell counts >350/μL and 12.5% in low CD4 group (<350/μL). 59 % and 29% were positive for TBGL-IgG and -IgA, respectively, in HIV-AC, but no association was found between QFT and TBGL assays. TBGL-IgG-positive rates in QFT-positive and QFT-negative HIV-AC were 61% and 58%, and those of TBGL-IgA were 23% and 30%, respectively. The titers of TBGL-IgA were associated with serum IgA (P=0.02) in HIV-AC. Elevations of TBGL-IgG and -IgA were related to latent tuberculosis infection in HCWs, but careful interpretation is necessary in HIV-AC.http://dx.doi.org/10.1155/2012/610707 |
| spellingShingle | Umme Ruman Siddiqi Prisca Susan A. Leano Haorile Chagan-Yasutan Beata Shiratori Hiroki Saitoh Yugo Ashino Yasuhiko Suzuki Toshio Hattori Elizabeth Freda O. Telan Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines Clinical and Developmental Immunology |
| title | Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines |
| title_full | Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines |
| title_fullStr | Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines |
| title_full_unstemmed | Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines |
| title_short | Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines |
| title_sort | frequent detection of anti tubercular glycolipid igg and iga antibodies in healthcare workers with latent tuberculosis infection in the philippines |
| url | http://dx.doi.org/10.1155/2012/610707 |
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