17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response
Neoadjuvant chemoradiation (CRT) followed by curative surgery still remains the standard of care for locally advanced rectal cancer (LARC). The main purpose of this multimodal treatment is to achieve a complete pathological tumor response (ypCR), with better survival. The surgery delay after CRT com...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2015/816491 |
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| author | Marisa D. Santos Manuel T. Gomes Filipa Moreno Anabela Rocha Carlos Lopes |
| author_facet | Marisa D. Santos Manuel T. Gomes Filipa Moreno Anabela Rocha Carlos Lopes |
| author_sort | Marisa D. Santos |
| collection | DOAJ |
| description | Neoadjuvant chemoradiation (CRT) followed by curative surgery still remains the standard of care for locally advanced rectal cancer (LARC). The main purpose of this multimodal treatment is to achieve a complete pathological tumor response (ypCR), with better survival. The surgery delay after CRT completion seems to increase tumor response and ypCR rate. Usually, time intervals range from 8 to 12 weeks, but the maximum tumor regression may not be seen in rectal adenocarcinomas until several months after CRT. About this issue, we report a case of a 52-year-old man with LARC treated with neoadjuvant CRT who developed, one month after RT completion, an acute myocardial infarction. The need to increase the interval between CRT and surgery for 17 weeks allowed a curative surgery without morbidity and an unexpected complete tumor response in the resected specimen (given the parameters presented in pelvic magnetic resonance imaging (MRI) performed 11 weeks after radiotherapy completion). |
| format | Article |
| id | doaj-art-0eb7eda32ab6450f955dd97f7d53d4c0 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-0eb7eda32ab6450f955dd97f7d53d4c02025-02-03T01:23:23ZengWileyCase Reports in Surgery2090-69002090-69192015-01-01201510.1155/2015/81649181649117-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological ResponseMarisa D. Santos0Manuel T. Gomes1Filipa Moreno2Anabela Rocha3Carlos Lopes4Department of Surgery, Digestive Surgery Service, Hospital de Santo António, Centro Hospitalar do Porto, Largo Professor Abel Salazar, 4099-003 Porto, PortugalDepartment of Medical Imaging, Radiology Service, Hospital de Santo António, Centro Hospitalar do Porto, Largo Professor Abel Salazar, 4099-003 Porto, PortugalDepartment of Pathology, Pathological Anatomy Service, Hospital de Santo António, Centro Hospitalar do Porto, Largo Professor Abel Salazar, 4099-003 Porto, PortugalDepartment of Surgery, Digestive Surgery Service, Hospital de Santo António, Centro Hospitalar do Porto, Largo Professor Abel Salazar, 4099-003 Porto, PortugalDepartment of Pathology, Pathological Anatomy Service, Hospital de Santo António, Centro Hospitalar do Porto, Largo Professor Abel Salazar, 4099-003 Porto, PortugalNeoadjuvant chemoradiation (CRT) followed by curative surgery still remains the standard of care for locally advanced rectal cancer (LARC). The main purpose of this multimodal treatment is to achieve a complete pathological tumor response (ypCR), with better survival. The surgery delay after CRT completion seems to increase tumor response and ypCR rate. Usually, time intervals range from 8 to 12 weeks, but the maximum tumor regression may not be seen in rectal adenocarcinomas until several months after CRT. About this issue, we report a case of a 52-year-old man with LARC treated with neoadjuvant CRT who developed, one month after RT completion, an acute myocardial infarction. The need to increase the interval between CRT and surgery for 17 weeks allowed a curative surgery without morbidity and an unexpected complete tumor response in the resected specimen (given the parameters presented in pelvic magnetic resonance imaging (MRI) performed 11 weeks after radiotherapy completion).http://dx.doi.org/10.1155/2015/816491 |
| spellingShingle | Marisa D. Santos Manuel T. Gomes Filipa Moreno Anabela Rocha Carlos Lopes 17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response Case Reports in Surgery |
| title | 17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response |
| title_full | 17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response |
| title_fullStr | 17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response |
| title_full_unstemmed | 17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response |
| title_short | 17-Week Delay Surgery after Chemoradiation in Rectal Cancer with Complete Pathological Response |
| title_sort | 17 week delay surgery after chemoradiation in rectal cancer with complete pathological response |
| url | http://dx.doi.org/10.1155/2015/816491 |
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