Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020
BackgroundAt present, the role of uric acid in mental disorders is receiving increasing attention, but its relationship with depression is controversial, and previous studies have corresponding limitations. The relationship between them has not been fully elucidated.ObjectiveThe purpose of this stud...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1544266/full |
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| author | Pengwei Lai Xingyun Xie Wen Zeng Weiwen Cheng Xinyuan Liu He Long Taierqi Peng Antong Hu Xiaohong Du |
| author_facet | Pengwei Lai Xingyun Xie Wen Zeng Weiwen Cheng Xinyuan Liu He Long Taierqi Peng Antong Hu Xiaohong Du |
| author_sort | Pengwei Lai |
| collection | DOAJ |
| description | BackgroundAt present, the role of uric acid in mental disorders is receiving increasing attention, but its relationship with depression is controversial, and previous studies have corresponding limitations. The relationship between them has not been fully elucidated.ObjectiveThe purpose of this study is to explore the relationship between uric acid and depression in American adults using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThis cross-sectional study included participants from the National Health and Nutrition Examination Survey 2011-2020. Use logistic regression and restricted cubic spline analysis to investigate the relationship between uric acid and depression. The interactions between variables were determined using subgroup analysis and described in a forest plot.Results37033 participants were included in this study, with depression patients accounting for 8.95%. The uric acid levels in the depression group and nondepression group were 317.69 μ mol/L and 323.34 μ mol/L, respectively, with the former having significantly lower uric acid levels than the latter. In the fully adjusted model, participants in the third tertile of uric acid showed a significant correlation (P=0.002, OR; 0.85 (0.76 ~ 0.94)) with a higher risk of depression compared to participants in the first tertile. There is an approximately linear negative correlation between uric acid and depression (P for nonlinear=0.360), and the OR value of uric acid is 1 when the uric acid value is 312.20 μ mol/L.ConclusionsCurrent research suggests that serum uric acid is associated with depression in American adults. More discoveries and causal relationships require further investigation. |
| format | Article |
| id | doaj-art-0eb42c7a6a5b4e2dba7e99b3fdb46a97 |
| institution | OA Journals |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-0eb42c7a6a5b4e2dba7e99b3fdb46a972025-08-20T02:09:25ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-06-011610.3389/fpsyt.2025.15442661544266Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020Pengwei Lai0Xingyun Xie1Wen Zeng2Weiwen Cheng3Xinyuan Liu4He Long5Taierqi Peng6Antong Hu7Xiaohong Du8The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaThe Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Anesthesiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaBackgroundAt present, the role of uric acid in mental disorders is receiving increasing attention, but its relationship with depression is controversial, and previous studies have corresponding limitations. The relationship between them has not been fully elucidated.ObjectiveThe purpose of this study is to explore the relationship between uric acid and depression in American adults using data from the National Health and Nutrition Examination Survey (NHANES).MethodsThis cross-sectional study included participants from the National Health and Nutrition Examination Survey 2011-2020. Use logistic regression and restricted cubic spline analysis to investigate the relationship between uric acid and depression. The interactions between variables were determined using subgroup analysis and described in a forest plot.Results37033 participants were included in this study, with depression patients accounting for 8.95%. The uric acid levels in the depression group and nondepression group were 317.69 μ mol/L and 323.34 μ mol/L, respectively, with the former having significantly lower uric acid levels than the latter. In the fully adjusted model, participants in the third tertile of uric acid showed a significant correlation (P=0.002, OR; 0.85 (0.76 ~ 0.94)) with a higher risk of depression compared to participants in the first tertile. There is an approximately linear negative correlation between uric acid and depression (P for nonlinear=0.360), and the OR value of uric acid is 1 when the uric acid value is 312.20 μ mol/L.ConclusionsCurrent research suggests that serum uric acid is associated with depression in American adults. More discoveries and causal relationships require further investigation.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1544266/fulluric aciddepressionNHANESdisease markerpublic health |
| spellingShingle | Pengwei Lai Xingyun Xie Wen Zeng Weiwen Cheng Xinyuan Liu He Long Taierqi Peng Antong Hu Xiaohong Du Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020 Frontiers in Psychiatry uric acid depression NHANES disease marker public health |
| title | Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020 |
| title_full | Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020 |
| title_fullStr | Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020 |
| title_full_unstemmed | Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020 |
| title_short | Relationship between uric acid and depression in American adults: findings from NHANES, 2005-2020 |
| title_sort | relationship between uric acid and depression in american adults findings from nhanes 2005 2020 |
| topic | uric acid depression NHANES disease marker public health |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1544266/full |
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