Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm
Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. In the current case, a cylindroma of the skin...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/4039545 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556723747946496 |
|---|---|
| author | A. Halima A. M. Pannunzio E. M. Erstine J. S. Ko W. F. Bergfeld R. M. Malaya M. B. Frankel B. C. Calhoun C. D. Sturgis |
| author_facet | A. Halima A. M. Pannunzio E. M. Erstine J. S. Ko W. F. Bergfeld R. M. Malaya M. B. Frankel B. C. Calhoun C. D. Sturgis |
| author_sort | A. Halima |
| collection | DOAJ |
| description | Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. In the current case, a cylindroma of the skin of the breast was diagnosed by complete excision. Immunohistochemical studies confirmed the tumor cells to be immunoreactive with cytokeratin AE1/3, cytokeratin 5/6, cytokeratin 7, p63, and SOX10. The neoplastic cells were also noted to be immunoreactive with markers typically expected to be positive in ductal epithelium of the breast including GATA3, mammaglobin, and E-cadherin. The case emphasizes the importance of correlating clinical setting, imaging studies, patient history, and careful microscopic evaluation in arriving at an accurate diagnosis. This case also illustrates the point that not all “breast” tumors that are confirmed to be positive for GATA3, mammaglobin, and E-cadherin are derived from mammary ducts. |
| format | Article |
| id | doaj-art-0eb3f8110fd14989af07d376c3b96a3a |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-0eb3f8110fd14989af07d376c3b96a3a2025-02-03T05:44:29ZengWileyCase Reports in Pathology2090-67812090-679X2018-01-01201810.1155/2018/40395454039545Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal NeoplasmA. Halima0A. M. Pannunzio1E. M. Erstine2J. S. Ko3W. F. Bergfeld4R. M. Malaya5M. B. Frankel6B. C. Calhoun7C. D. Sturgis8RJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USARJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USARJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USARJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USARJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USAGeneral Surgery, Cleveland Clinic, Cleveland, OH, USADiagnostic Radiology, Cleveland Clinic, Cleveland, OH, USARJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USARJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USACylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. In the current case, a cylindroma of the skin of the breast was diagnosed by complete excision. Immunohistochemical studies confirmed the tumor cells to be immunoreactive with cytokeratin AE1/3, cytokeratin 5/6, cytokeratin 7, p63, and SOX10. The neoplastic cells were also noted to be immunoreactive with markers typically expected to be positive in ductal epithelium of the breast including GATA3, mammaglobin, and E-cadherin. The case emphasizes the importance of correlating clinical setting, imaging studies, patient history, and careful microscopic evaluation in arriving at an accurate diagnosis. This case also illustrates the point that not all “breast” tumors that are confirmed to be positive for GATA3, mammaglobin, and E-cadherin are derived from mammary ducts.http://dx.doi.org/10.1155/2018/4039545 |
| spellingShingle | A. Halima A. M. Pannunzio E. M. Erstine J. S. Ko W. F. Bergfeld R. M. Malaya M. B. Frankel B. C. Calhoun C. D. Sturgis Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm Case Reports in Pathology |
| title | Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm |
| title_full | Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm |
| title_fullStr | Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm |
| title_full_unstemmed | Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm |
| title_short | Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm |
| title_sort | cutaneous adnexal cylindroma of breast epithelial immunoreactivities for gata 3 mammaglobin and e cadherin do not equate to a mammary ductal neoplasm |
| url | http://dx.doi.org/10.1155/2018/4039545 |
| work_keys_str_mv | AT ahalima cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT ampannunzio cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT emerstine cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT jsko cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT wfbergfeld cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT rmmalaya cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT mbfrankel cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT bccalhoun cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm AT cdsturgis cutaneousadnexalcylindromaofbreastepithelialimmunoreactivitiesforgata3mammaglobinandecadherindonotequatetoamammaryductalneoplasm |