Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness
Tenderness is one of the most important indicators to judge meat quality, and it is also the most important sensory index for consumers to choose meat. Postmortem muscle undergoes complex biochemical processes, and apoptosis is considered to be a key biochemical pathway to regulate postmortem muscle...
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China Food Publishing Company
2025-02-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-3-029.pdf |
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| author | DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong |
| author_facet | DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong |
| author_sort | DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong |
| collection | DOAJ |
| description | Tenderness is one of the most important indicators to judge meat quality, and it is also the most important sensory index for consumers to choose meat. Postmortem muscle undergoes complex biochemical processes, and apoptosis is considered to be a key biochemical pathway to regulate postmortem muscle tenderization. Lysosomes are rich in cathepsins, and a large amount of cathepsins are released after lysosomal membrane permeabilization, which activates the caspase cascade through the intrinsic lysosomal-mitochondrial pathway, triggering apoptosis and consequently accelerating postmortem muscle tenderization. This article introduces the action mechanism and metabolic processes of lysosomes and elaborates the activation pathways of lysosomal membrane permeabilization through reactive oxygen species (ROS), sphingosine, B-cell lymphoma-2 (Bcl-2) and p53 proteins. Furthermore, it explores the pathway for the involvement of lysosomes in apoptosis, and summarizes the regulatory mechanism of lysosomes on muscle tenderization from the perspectives of the release of cathepsins and Ca2+, caspase activation and iron-induced oxidative stress. We hope that this review can provide a theoretical reference for improving meat tenderness. |
| format | Article |
| id | doaj-art-0eae44f462154088a87305ce300f468e |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-0eae44f462154088a87305ce300f468e2025-02-05T09:08:33ZengChina Food Publishing CompanyShipin Kexue1002-66302025-02-0146325726610.7506/spkx1002-6630-20240718-191Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat TendernessDONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong0(1. School of Food Science and Engineering, Ningxia University, Yinchuan 750021, China;2. Yinchuan Agricultural Product Quality Testing Center, Yinchuan 750000, China;3. Inner Mongolia Vocational College of Chemical Engineering, Hohhot 010070, China)Tenderness is one of the most important indicators to judge meat quality, and it is also the most important sensory index for consumers to choose meat. Postmortem muscle undergoes complex biochemical processes, and apoptosis is considered to be a key biochemical pathway to regulate postmortem muscle tenderization. Lysosomes are rich in cathepsins, and a large amount of cathepsins are released after lysosomal membrane permeabilization, which activates the caspase cascade through the intrinsic lysosomal-mitochondrial pathway, triggering apoptosis and consequently accelerating postmortem muscle tenderization. This article introduces the action mechanism and metabolic processes of lysosomes and elaborates the activation pathways of lysosomal membrane permeabilization through reactive oxygen species (ROS), sphingosine, B-cell lymphoma-2 (Bcl-2) and p53 proteins. Furthermore, it explores the pathway for the involvement of lysosomes in apoptosis, and summarizes the regulatory mechanism of lysosomes on muscle tenderization from the perspectives of the release of cathepsins and Ca2+, caspase activation and iron-induced oxidative stress. We hope that this review can provide a theoretical reference for improving meat tenderness.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-3-029.pdflysosome; membrane permeabilization; cathepsin; apoptosis; lysosomal iron; tenderness |
| spellingShingle | DONG Yushan, DU Rui, SU Rina, YAO Lili, DU Xuerong, LI Chenlong, WU Junqin, HOU Yanru, LUO Yulong Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness Shipin Kexue lysosome; membrane permeabilization; cathepsin; apoptosis; lysosomal iron; tenderness |
| title | Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness |
| title_full | Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness |
| title_fullStr | Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness |
| title_full_unstemmed | Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness |
| title_short | Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness |
| title_sort | research progress on metabolic regulation of lysosomes and their regulatory mechanism on meat tenderness |
| topic | lysosome; membrane permeabilization; cathepsin; apoptosis; lysosomal iron; tenderness |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-3-029.pdf |
| work_keys_str_mv | AT dongyushanduruisurinayaoliliduxueronglichenlongwujunqinhouyanruluoyulong researchprogressonmetabolicregulationoflysosomesandtheirregulatorymechanismonmeattenderness |