Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method
The presence of the skull hinders photoacoustic imaging from being used for brain imaging. In order to understand the mechanism of photoacoustic signal generation of cerebrovascular in the presence of skull, a photoacoustic model of cerebrovascular was established by using COMSOL Multiphysics to ach...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2025-01-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/5.0244703 |
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| author | Shangkun Hou Anzhi Lv Jiabin Lin Bokang You Shuaixin Huang Xianlin Song |
| author_facet | Shangkun Hou Anzhi Lv Jiabin Lin Bokang You Shuaixin Huang Xianlin Song |
| author_sort | Shangkun Hou |
| collection | DOAJ |
| description | The presence of the skull hinders photoacoustic imaging from being used for brain imaging. In order to understand the mechanism of photoacoustic signal generation of cerebrovascular in the presence of skull, a photoacoustic model of cerebrovascular was established by using COMSOL Multiphysics to achieve the visualization of the whole process of the generation and transmission of the cerebrovascular photoacoustic signal. The diffusion equation is approximated by the partial differential equations in the form of coefficients in the mathematical module of COMSOL to describe laser propagation in brain tissue. The light energy absorbed by the gray matter and blood vessels was used as a heat source, and the biological heat transfer module of COMSOL Multiphysics was used to describe the instantaneous temperature rise of gray matter and blood vessels. A thermal strain model was constructed by the solid mechanics module to visualize the surface displacement caused by the adiabatic expansion of blood vessels. The photoacoustic signal is generated by the surface displacement of the vessel, and the propagation of the photoacoustic signal is visualized using a transient pressure acoustic model of COMSOL Multiphysics. This visualization study provides theoretical guidance for the research and application of photoacoustic imaging in brain structural and functional imaging. |
| format | Article |
| id | doaj-art-0ead73771f5b49d4be0e13a89755b581 |
| institution | Kabale University |
| issn | 2158-3226 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj-art-0ead73771f5b49d4be0e13a89755b5812025-02-03T16:40:43ZengAIP Publishing LLCAIP Advances2158-32262025-01-01151015324015324-910.1063/5.0244703Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling methodShangkun Hou0Anzhi Lv1Jiabin Lin2Bokang You3Shuaixin Huang4Xianlin Song5School of Information Engineering, Nanchang University, Nanchang 330031, ChinaSchool of Information Engineering, Nanchang University, Nanchang 330031, ChinaSchool of Information Engineering, Nanchang University, Nanchang 330031, ChinaSchool of Information Engineering, Nanchang University, Nanchang 330031, ChinaJiluan Academy, Nanchang University, Nanchang 330031, ChinaSchool of Information Engineering, Nanchang University, Nanchang 330031, ChinaThe presence of the skull hinders photoacoustic imaging from being used for brain imaging. In order to understand the mechanism of photoacoustic signal generation of cerebrovascular in the presence of skull, a photoacoustic model of cerebrovascular was established by using COMSOL Multiphysics to achieve the visualization of the whole process of the generation and transmission of the cerebrovascular photoacoustic signal. The diffusion equation is approximated by the partial differential equations in the form of coefficients in the mathematical module of COMSOL to describe laser propagation in brain tissue. The light energy absorbed by the gray matter and blood vessels was used as a heat source, and the biological heat transfer module of COMSOL Multiphysics was used to describe the instantaneous temperature rise of gray matter and blood vessels. A thermal strain model was constructed by the solid mechanics module to visualize the surface displacement caused by the adiabatic expansion of blood vessels. The photoacoustic signal is generated by the surface displacement of the vessel, and the propagation of the photoacoustic signal is visualized using a transient pressure acoustic model of COMSOL Multiphysics. This visualization study provides theoretical guidance for the research and application of photoacoustic imaging in brain structural and functional imaging.http://dx.doi.org/10.1063/5.0244703 |
| spellingShingle | Shangkun Hou Anzhi Lv Jiabin Lin Bokang You Shuaixin Huang Xianlin Song Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method AIP Advances |
| title | Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method |
| title_full | Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method |
| title_fullStr | Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method |
| title_full_unstemmed | Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method |
| title_short | Insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi-physics coupling method |
| title_sort | insight on the complete process of photoacoustic generation and propagation of cerebrovascular in brain via multi physics coupling method |
| url | http://dx.doi.org/10.1063/5.0244703 |
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