Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy

Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy

Background The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its susceptibility to neutralization by IL-18 binding protein (IL-18BP), short in vivo half-life, and...

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Main Authors: Yue Zhao, Yan Qu, Marina Moskalenko, Dawei Sun, Travis W Bainbridge, Matthieu Masureel, Lifen Wang, Robert Herrera, Maciej T Paluch, Kazi Tasneem, Harpinder Saini, Manal Sadek, Mandy Kwong, Yoon Min Kim, Jay M Bhatt, Christine Tam, Pamela Pui Fung Chan, Ayse Meric Ovacik, Jonathan T Sockolosky, Nathaniel R West, Beyza Bulutoglu
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011789.full
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