The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization

The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization

Abstract Background It remains controversial whether lipids affect osteoporosis (OP) or bone mineral density (BMD), and causality has not been established. This study aimed to investigate the genetic associations between lipids, novel non-statin lipid-lowering drug target genes, and OP and BMD. Meth...

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Bibliographic Details
Main Authors: Qingcong Zheng, Rongjie Lin, Du Wang, Rongsheng Chen, Weihong Xu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoporosis
Bone mineral density
Lipids
ANGPTL3
APOC3
Drug target Mendelian randomization
Online Access:https://doi.org/10.1186/s12891-024-08160-z
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