Identification of a postoperative survival scoring index for adult liver transplantation
Background In addition to surgical technology, successful liver transplantation (LT) depends on perioperative management, which needs an effective prognostic index. Therefore, a simplified and sensitive postoperative index for adult LT should be developed.Methods In total, 906 patients who underwent...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2458212 |
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| author | Shuai Wang Xiaohong Lin Yefu Li Zhonghao Xie Ming Zhang Yicheng Liang Chuchen Zhu Yuqi Dong Ping Zeng Xiaoshun He Weiqiang Ju Maogen Chen |
| author_facet | Shuai Wang Xiaohong Lin Yefu Li Zhonghao Xie Ming Zhang Yicheng Liang Chuchen Zhu Yuqi Dong Ping Zeng Xiaoshun He Weiqiang Ju Maogen Chen |
| author_sort | Shuai Wang |
| collection | DOAJ |
| description | Background In addition to surgical technology, successful liver transplantation (LT) depends on perioperative management, which needs an effective prognostic index. Therefore, a simplified and sensitive postoperative index for adult LT should be developed.Methods In total, 906 patients who underwent LT were included in this cross-sectional study. Univariate analysis was used to identify the independent risk factors for recipient survival. Multivariate logistic and stepwise regression analyses were used to construct and simplify the model design. Area under the curve (AUC) and Kaplan–Meier’s (K–M) analysis demonstrated superiority of the new index. The postoperative survival score (POSS) index was further simplified via restricted cubic spline (RCS) analysis. Finally, the interpretation of the long-term mortality and subgroup analyses extended the application of the POSS index.Results Finally, a total of five factors (donor sex, recipient body mass index (BMI), total bilirubin (Tbil), international normalized ratio (INR) and total operative time) were identified as independent risk parameters and included in our POSS index. The AUCs of the original and simplified POSS indices were 0.764 and 0.723, respectively. Patients with high scores had poor short-term survival. Our index also functioned well in predicting long-term mortality, and it was more effective for patients with hepatitis B cirrhosis or hepatocellular carcinoma (HCC).Conclusions We constructed a simplified and effective postoperative survival scoring index to predict short-term complications and survival in adult LT patients. |
| format | Article |
| id | doaj-art-0e7f2247ce9348e1914724989f4dd8be |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-0e7f2247ce9348e1914724989f4dd8be2025-02-04T16:35:18ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2458212Identification of a postoperative survival scoring index for adult liver transplantationShuai Wang0Xiaohong Lin1Yefu Li2Zhonghao Xie3Ming Zhang4Yicheng Liang5Chuchen Zhu6Yuqi Dong7Ping Zeng8Xiaoshun He9Weiqiang Ju10Maogen Chen11Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaDepartment of Breast and Thyroid Surgery, Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaOrgan Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR ChinaBackground In addition to surgical technology, successful liver transplantation (LT) depends on perioperative management, which needs an effective prognostic index. Therefore, a simplified and sensitive postoperative index for adult LT should be developed.Methods In total, 906 patients who underwent LT were included in this cross-sectional study. Univariate analysis was used to identify the independent risk factors for recipient survival. Multivariate logistic and stepwise regression analyses were used to construct and simplify the model design. Area under the curve (AUC) and Kaplan–Meier’s (K–M) analysis demonstrated superiority of the new index. The postoperative survival score (POSS) index was further simplified via restricted cubic spline (RCS) analysis. Finally, the interpretation of the long-term mortality and subgroup analyses extended the application of the POSS index.Results Finally, a total of five factors (donor sex, recipient body mass index (BMI), total bilirubin (Tbil), international normalized ratio (INR) and total operative time) were identified as independent risk parameters and included in our POSS index. The AUCs of the original and simplified POSS indices were 0.764 and 0.723, respectively. Patients with high scores had poor short-term survival. Our index also functioned well in predicting long-term mortality, and it was more effective for patients with hepatitis B cirrhosis or hepatocellular carcinoma (HCC).Conclusions We constructed a simplified and effective postoperative survival scoring index to predict short-term complications and survival in adult LT patients.https://www.tandfonline.com/doi/10.1080/07853890.2025.2458212Liver transplantationshort-term survivalmalignant liver diseaseMELD score |
| spellingShingle | Shuai Wang Xiaohong Lin Yefu Li Zhonghao Xie Ming Zhang Yicheng Liang Chuchen Zhu Yuqi Dong Ping Zeng Xiaoshun He Weiqiang Ju Maogen Chen Identification of a postoperative survival scoring index for adult liver transplantation Annals of Medicine Liver transplantation short-term survival malignant liver disease MELD score |
| title | Identification of a postoperative survival scoring index for adult liver transplantation |
| title_full | Identification of a postoperative survival scoring index for adult liver transplantation |
| title_fullStr | Identification of a postoperative survival scoring index for adult liver transplantation |
| title_full_unstemmed | Identification of a postoperative survival scoring index for adult liver transplantation |
| title_short | Identification of a postoperative survival scoring index for adult liver transplantation |
| title_sort | identification of a postoperative survival scoring index for adult liver transplantation |
| topic | Liver transplantation short-term survival malignant liver disease MELD score |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2458212 |
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