Narcolepsy: Pathophysiology and Neuropsychological Changes

Narcolepsy is now recognized as a distinctive disorder with specific pathophysiology and neurochemical abnormalities. Findings on the role of the neuropeptide hypocretin are opening new avenues of research and new strategies for therapy. Recently, neuropsychological and electrophysiological studies...

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Main Authors: Angela Naumann, Irene Daum
Format: Article
Language:English
Published: Wiley 2003-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.1155/2003/323060
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author Angela Naumann
Irene Daum
author_facet Angela Naumann
Irene Daum
author_sort Angela Naumann
collection DOAJ
description Narcolepsy is now recognized as a distinctive disorder with specific pathophysiology and neurochemical abnormalities. Findings on the role of the neuropeptide hypocretin are opening new avenues of research and new strategies for therapy. Recently, neuropsychological and electrophysiological studies have provided evidence for reduced memory performance on standard memory tests in addition to subjective complaints of forgetfulness which may be related to changes in attentional processing. Further studies are, however, necessary to clarify the neuropsychological profile in narcolepsy. This review focuses on the recent advances in understanding narcolepsy.
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spelling doaj-art-0e7453aab1dc4147a34ebe740834902f2025-02-03T01:20:47ZengWileyBehavioural Neurology0953-41801875-85842003-01-01143-4899810.1155/2003/323060Narcolepsy: Pathophysiology and Neuropsychological ChangesAngela Naumann0Irene Daum1Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr-University of Bochum, GermanyDepartment of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr-University of Bochum, GermanyNarcolepsy is now recognized as a distinctive disorder with specific pathophysiology and neurochemical abnormalities. Findings on the role of the neuropeptide hypocretin are opening new avenues of research and new strategies for therapy. Recently, neuropsychological and electrophysiological studies have provided evidence for reduced memory performance on standard memory tests in addition to subjective complaints of forgetfulness which may be related to changes in attentional processing. Further studies are, however, necessary to clarify the neuropsychological profile in narcolepsy. This review focuses on the recent advances in understanding narcolepsy.http://dx.doi.org/10.1155/2003/323060
spellingShingle Angela Naumann
Irene Daum
Narcolepsy: Pathophysiology and Neuropsychological Changes
Behavioural Neurology
title Narcolepsy: Pathophysiology and Neuropsychological Changes
title_full Narcolepsy: Pathophysiology and Neuropsychological Changes
title_fullStr Narcolepsy: Pathophysiology and Neuropsychological Changes
title_full_unstemmed Narcolepsy: Pathophysiology and Neuropsychological Changes
title_short Narcolepsy: Pathophysiology and Neuropsychological Changes
title_sort narcolepsy pathophysiology and neuropsychological changes
url http://dx.doi.org/10.1155/2003/323060
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AT irenedaum narcolepsypathophysiologyandneuropsychologicalchanges