Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000
Three new structures named naphpyrone I–K (<b>1</b>–<b>3</b>) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived <i>Streptomyces</i> sp. HDN155000. Their chemical structures, including configurations, were elucid...
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MDPI AG
2025-04-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/5/188 |
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| author | Xiaoting Zhang Falei Zhang Wenxue Wang Xingtao Ren Tianjiao Zhu Qian Che Dehai Li Guojian Zhang |
| author_facet | Xiaoting Zhang Falei Zhang Wenxue Wang Xingtao Ren Tianjiao Zhu Qian Che Dehai Li Guojian Zhang |
| author_sort | Xiaoting Zhang |
| collection | DOAJ |
| description | Three new structures named naphpyrone I–K (<b>1</b>–<b>3</b>) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived <i>Streptomyces</i> sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, and ECD analyses. Naphpyrone K (<b>3</b>) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, and NCI-H446 cancer cells with IC<sub>50</sub> values of 5.13, 3.34, 2.50, 2.61, and 2.20 μM, respectively. These findings highlight the potential for screening and developing therapeutic drugs from aromatic polyketides derived from marine actinobacteria. |
| format | Article |
| id | doaj-art-0e6f1c3f11d4412cabb9bc1c48986df4 |
| institution | OA Journals |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-0e6f1c3f11d4412cabb9bc1c48986df42025-08-20T02:33:57ZengMDPI AGMarine Drugs1660-33972025-04-0123518810.3390/md23050188Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000Xiaoting Zhang0Falei Zhang1Wenxue Wang2Xingtao Ren3Tianjiao Zhu4Qian Che5Dehai Li6Guojian Zhang7Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaThree new structures named naphpyrone I–K (<b>1</b>–<b>3</b>) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived <i>Streptomyces</i> sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, and ECD analyses. Naphpyrone K (<b>3</b>) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, and NCI-H446 cancer cells with IC<sub>50</sub> values of 5.13, 3.34, 2.50, 2.61, and 2.20 μM, respectively. These findings highlight the potential for screening and developing therapeutic drugs from aromatic polyketides derived from marine actinobacteria.https://www.mdpi.com/1660-3397/23/5/188actinobacteriapolyketidecytotoxic activity |
| spellingShingle | Xiaoting Zhang Falei Zhang Wenxue Wang Xingtao Ren Tianjiao Zhu Qian Che Dehai Li Guojian Zhang Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000 Marine Drugs actinobacteria polyketide cytotoxic activity |
| title | Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000 |
| title_full | Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000 |
| title_fullStr | Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000 |
| title_full_unstemmed | Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000 |
| title_short | Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000 |
| title_sort | polyketides with a 6 6 6 6 oxaphenalene pyranone skeleton from marine derived i streptomyces i sp hdn150000 |
| topic | actinobacteria polyketide cytotoxic activity |
| url | https://www.mdpi.com/1660-3397/23/5/188 |
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